Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1986-09-10
1991-04-09
Moskowitz, Margaret
Drug, bio-affecting and body treating compositions
Lymphokine
424 86, 424 93, 4352351, 435236, 435237, A61K 3912, C12N 700
Patent
active
050063359
ABSTRACT:
The invention relates to a live vaccine against mumps, which contains live mumps viruses which are capable of multiplication and have been attenuated principally by passages in diploid human tissue cultures. The vaccine is substantially free from proteins and antibiotics.
The invention also relates to the process for the preparation of a live vaccine against mumps, which comprises obtaining live mumps viruses from the urine of patients with an acute attack of mumps, passaging the viruses in diploid human cells, thereby attenuating the viruses by repeated passages in tissue of this type and, optionally further attenuating the viruses by passaging in embryonic or fertilized chicken eggs, optionally further attenuating the viruses by further passaging in diploid human cells, thereby adapting the viruses to human tissue, isolating, cultivating, and then processing the live mumps viruses.
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patent: 3555149 (1971-01-01), Buynak et al.
patent: 3829361 (1974-08-01), Hoshino et al.
patent: 3961046 (1976-06-01), Cerini
patent: 4324861 (1982-04-01), Kan
CMAJ 138: 135 (1988).
Lancet, p. 394 (Aug. 12, 1989).
Esact Meeting 8th: 1987, p. 587.
Canada Diseases, Weekly Report, p. 209 (1988).
Canada Diseases, Weekly Report, p. 155 (1987).
Lancet, p. 677, Sep. 16, 1989.
Lancet, p. 751, Sep. 23, 1989.
BMJ, 299: 660 (1989).
Germanier Rene
Gluck Reinhard
Institute for the Research of Infectious Diseases
Kile Bradford E.
Mohamed Abdel A.
Moskowitz Margaret
Swiss Serum & Vaccine Institute
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