Live salmonella vaccine having an increased stability

Details Live salmonella vaccine having an increased stability Live salmonella vaccine having an increased stability

1994-10-03

1998-08-11

Naff, David M.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Bacteria or actinomycetales

4242781, 4242821, 424821, 424826, 4242581, 435245, 4352522, A61K 4500, A61K 4505, A01N 6300, C12N 136

Patent

active

057924520

ABSTRACT:
A live Salmonella vaccine having an increased stability is disclosed. Further, immunization methods of a host such as chickens against Salmonella diseases are carried out by the use of the vaccine. The vaccine may be administered orally or parenterally and includes one or more of the live vaccines disclosed herein. The live vaccine is produced from one or more live vaccine strains with metabolic drift attenuation via an increased generation time. The vaccine is an immunogenic, stable and single or multiple marker live vaccine strain with or without envelope mutation; and the live vaccine is a suppressor mutant of an original live vaccine strain still having the attenuation marker(s) of the original live vaccine strain but a shortened generation time and having macrolide tolerance.

REFERENCES:
patent: 4472378 (1984-09-01), Shuster et al.
patent: 4687737 (1987-08-01), Sharp et al.
Linde, K. Arch. Exper. Vet. Med. Salmonella mutants with shortened generation times. vol. 36, pp. 237-242, Feb. 2, 1982.
Linde et al., "Prophylaxis of Salmonella abortus ovis-induced abortion of sheep . . . " 1992, pp. 337--340.
Linde et al. "Stabe Listeria monocytogenes live vaccine candidate strains . . . ", 1991, pp. 101-105.

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