Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1975-04-18
1976-06-08
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Lymphokine
195 11, 195 13, A61K 3918
Patent
active
039624234
ABSTRACT:
Attenuated stable influenza type B virus strains are obtained by recombining a vaccinal and previously attenuated influenza type B virus strain with an influenza type B virus isolate having the desired serotype and isolating a recombinant having at least one marker property of the attenuated parent strain which is not shared by the other parent strain and the antigenic composition of the other parent strain. The obtained strains are useful for the production of nasal influenza vaccines.
REFERENCES:
peetermans, J. et al., Dev. Biol. Stand, vol. 28: 340-346 (1975) "Immune Response to Combined Live Influenza Virus Vaccines Administered Intranasally."
Kilbourne, E. D. et al., J. Infect. Dis. 124(5): 449-462 (1971) "Correlated Studies of a Recombinant Influenza Virus Vaccine I."
Schulman, J. L. et al., J. Infect. Dis. 124(5): 463-472 (1971) "Correlated Studies of a Recombinant Influenza Virus Vaccine II."
Kilbourne, E. D., Hospital Practice, Oct. 1971, "Influenza: The Vaccines" pp. 103-114.
Fazekas de St. Groth, S. Bull. Wld. Hlth. Org. 41: 651-657 (1969) "New Criteria for the Selection of Influenza Vaccine Strains".
Lobmann Michele
Peetermans Julien
Prevost Jean-Marie
Vascoboinic Emil
Edgerton William H.
Lourie Alan D.
Recherche et Industrie Therapeutiques (R.I.T.)
Rose Shep K.
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