Live genetically attenuated malaria vaccine

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing

Reexamination Certificate

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Details

C424S093200, C424S093210, C424S093700

Reexamination Certificate

active

11513649

ABSTRACT:
Method for inoculating a vertebrate host against malaria, by administering to the host a livePlasmodiumorganism that is genetically engineered to disrupt a liver-stage-specific gene function.

REFERENCES:
patent: 4681762 (1987-07-01), Oeschger et al.
patent: 6656479 (2003-12-01), Brake et al.
patent: WO95/07094 (1995-03-01), None
patent: WO 00/08165 (2000-02-01), None
patent: WO 2004/026903 (2004-04-01), None
patent: WO 2004/045559 (2004-06-01), None
Butler, D., “Mosquito Production Mooted as Fast Track to Malaria Vaccine,”Nature 425:437, 2003.
Doolan, D.L., and S.L. Hoffman, “The Complexity of Protective Immunity Against Liver-Stage Malaria,”Journal of Immunology 165:1453-1462, 2000.
Fandeur, T., et al., “Protection of Squirrel Monkeys Against VirulentPlasmodium falciparumInfections by Use of Attenuated Parasites,”Infection and Immunity 60(4):1390-1396, 1992.
Guerin-Marchand, C., et al., “A Liver-Stage-Specific Antigen ofPlasmodium falciparumCharacterized by Gene Cloning,”Nature 329:164-167, 1987.
Hoffman, S., “Save the Children,”Nature 430:940-941, 2004.
Hoffman, S.L., and D.L. Doolan, “Malaria Vaccines-Targeting Infected Hepatocytes,”Nature Medicine 6(11):1218-1219, 2000.
Hoffman, S.L., et al., “Protection of Human Against Malaria by Immunization With Radiation-AttenuatedPlasmodium falciparumSporozoites,”Journal of Infectious Diseases 185:1155-1164, 2002.
James, S., and L. Miller, “Malaria Vaccine Development: Status Report,” Niaid.nih.gov, Jan. 5, 2001, <http://www.niaid.nih.gov/dmid/malaria/malariavac.htm> [retrieved Oct. 15, 2004].
Kaiser, K., et al., “Differential Transcriptome Profiling IdentifiesPlasmodiumGenes Encoding Pre-Erythrocytic Stage-Specific Proteins,”Molecular Microbiology, 2004, pp. 1221-1232.
Kappe, S.H.I., et al., “PlasmodiumSporozoite Molecular Cell Biology,”Annual Review of Cell and Developmental Biology 20:29-59, 2004.
Luke, T.C., and S.L. Hoffman, “Rationale and Plans for Developing a Non-Replicating, Metabolically Active, Radiation-AttenuatedPlasmodium falciparumSporozoite Vaccine,”Journal of Experimental Biology 206:3803-3808, 2003.
Matuschewski, K., et al., Infectivity-Associated Changes in the Transcriptional Repertoire of the Malaria Parasite Sporozite Stage,Journal of Biological Chemistry 277(4):41948-41953, 2002.
Ménard, R., “Knockout Malaria Vaccine?”Nature 433:113-114,2005.
Ménard, R., and C. Janse, “Gene Targeting in Malaria Parasites,”METHODS: A Companion to Methods in Enzymology 13(2):148-157, 1997.
Ménard, R., et al., “Circumsporozoite Protein Is Required for Development of Malaria Sporozoites in Mosquitoes,”Nature 385(6614):336-340, 1997.
Mueller, A.-K., et al., Genetically ModifiedPlasmodiumParasites as a Protective Experimental Malaria Vaccine,Nature 433(7022):164-167, 2005.
Mueller, A.-K., et al., “PlasmodiumLiver Stage Developmental Arrest by Depletion of a Protein at the Parasite-Host Interface,”Proc. Natl. Acad. Sci. USA 102(8):3022-3027, 2005.
“Parasitic and Tropical Infections,”The Jordan Report: Accelerated Development of Vaccines, National Institutes of Health, 2000, pp. 25-30.
Scheller, L., and A.F. Azad, “Maintenance of Protective Immunity Against Malaria by Persistent Hepatic Parasites Derived From Irradiated Sporozoites,”Proc. Natl. Acad. Sci. USA 92:4066-4068, 1995.
Silvie, O., et al., “Effects of Irradiation onPlasmodium falciparumSporozoite Hepatic Development: Implications for the Design of Pre-Erythrocytic Malaria Vaccines,”Parasite Immunology 24(4):221-223, 2002.
Sultan. A.A., et al., “TRAP Is Necessary for Gliding Motility and Infectivity ofPlasmodiumSporozoites,”Cell 90(3):511-522, 1997.
Suzuki, M., et al., “An Alternative Approach to Malaria Vaccine With a Permanent Attenuated Mutant From a High VirulencePlasmodium bergheiStrain,”Zentralblatt fuer Bakteriologie, Mikrobiologie und Hygiene 264(3-4):319-325, 1987 (abstract provided).
van Dijk, M.R., et al., “A Central Role for P48/45 in Malaria Parasite Male Gamete Fertility,”Cell 104(1):153-164, 2001.
Waters, A.P., et al., “Malaria Vaccines: Back to the Future?”Science 307:528-530, 2005.
Worthey, E.A., and P.J. Myler, Invited review, “Protozoan Genomes: Gene Identification and Annotation,”International Journal for Parasitology 35:495-512, 2005.

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