Live, avirulent salmonella choleraesuis vaccine used for inducin

Details Live, avirulent salmonella choleraesuis vaccine used for inducin Live, avirulent salmonella choleraesuis vaccine used for inducin

1995-05-24

1996-12-03

Naff, David M.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Bacteria or actinomycetales

435245, 4352521, 4352528, 435879, A01N 6300, C12N 136, C12N 120

Patent

active

055805574

ABSTRACT:
Disclosed herein are methods for attenuating virulent gram negative bacteria to produce avirulent bacteria. The methods comprise passaging the wild-type bacteria through phagocytic cells, such as macrophages or polymorphonuclear leukocytes, or through lysosomes derived from such cells, a sufficient number of times until the bacteria become avirulent to the animal host. The bacteria are preferably from the family Enterobacteracea and most preferably from the genus Salmonellae. The invention further comprises the avirulent bacteria produced by the methods, pure cultures of such bacteria, and methods of using the bacteria, preferably in a vaccine for administration to an animal host to induce an immune response to the wild-type gram negative bacteria in the host.

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