Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Bacteria or actinomycetales
Patent
1993-07-19
1995-07-25
Knode, Marian C.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Bacteria or actinomycetales
435245, 4352521, 4352528, 435879, A61K 3912, C12N 136, C12N 120, C12N 100
Patent
active
054360013
ABSTRACT:
Disclosed herein are methods for attenuating virulent gram negative bacteria to produce avirulent bacteria. The methods comprise passaging the wild-type bacteria through phagocytic cells, such as macrophages or polymorphonuclear leukocytes, or through lysosomes derived from such cells, a sufficient number of times until the bacteria become avirulent to the animal host. The bacteria are preferably from the family Enterobacteracea and most preferably from the genus Salmonellae. The invention further comprises the avirulent bacteria produced by the methods, pure cultures of such bacteria, and methods of using the bacteria, preferably in a vaccine for administration to an animal host to induce an immune response to the wild-type gram negative bacteria in the host.
REFERENCES:
patent: 3907987 (1975-09-01), Wilson
patent: 3950512 (1976-04-01), Emery et al.
patent: 3975517 (1976-08-01), Wilson
patent: 4503036 (1985-03-01), Girardon et al.
patent: 4764370 (1988-08-01), Fields et al.
Kramer et al., Am. J. Vet. Res., 53 (4) 1992 pp. 444-448.
Sluzewska et al, Pol. Arch. Weter, 18 (2) 1975 (Recd 1976) pp.161-174.
Smith and Jones, "Observations on Experimental Oral Infection with Salmonella dublin in Calves and Salmonella choleraesuis in Pigs," J. Pathol. Bacteriol., 93:141-156 (1967).
Letter of Jun. 17, 1993 from C. Wray, Central Veterinary Laboratory, New Haw, Addlestone, Surrey, United Kingdom to Professor T. T. Kramer, Iowa State University, Ames, Iowa with two enclosures.
Lawson & Dow, "Experimental Vaccination of Pigs with Avirulent Rough Strains of Salmonella cholerae suis," Brit. Vet. J., 121:521-531 (1965).
Scholl and Grunert, "Suisaloral Dessau-Ein Salmonella-cholerae-suis-lebendimpf-stoff zur oralen, parenteralen und Kombinierten Anwendung," Arch. Exper. Vet. Med., (leipzig), 34:91-97 (1980).
Turfano et al., Microbial Pathogenesis, 7:337-346 (1989).
Gulig, Microbial Pathogenesis, 8:3-11 (1990).
Buchmeier et al. Infection and Immunity, 57:1-7 (1989).
Fields et al., Science, 243:1059-1062 (1989).
Buchmeier et al., Science, 248:730-732 (1990).
Griffith et al., Am. J. Vet. Res., 45:1342-1348 (1984).
Fields et al., Proc. Natl. Acad. Sci., 83:5189-5193 (1986).
Maurelli, Microbial Pathogenesis, 7:1-10 (1989).
Groisman et al., Proc. Natl. Acad. Sci., 86:7077-7081 (1989).
Finlay et al., J. of NIH Res., 1:84-87 (1989).
Dougan et al., Adv. Ve. Rad. Vet. Sci. and Comp. Med., 33:271-300 (1989).
Roof et al. Vet. Immunology & Immunopathology, 23 (3-4), 1989, pp. 365-376 (Biosis Abstract #89083449).
Griffith et al. Vet. Immunology & Immunopathology, 4, (1983) pp. 593-601.
Mungar et al. Abstracts of the Annual Meeting, 1983, (E98) p. 92.
Kramer et al. Am. J. Vet. Res., vol. 48, No. 7, Jul. 1987, pp. 1072-1076.
Finlay et al. J. Cell. Biol., 107:221-230 (1988).
Roof et al., "Characterization of a Salmonella choleraesuis, Isolate After Repeated Neutrophil Exposure," Amer. J. Vet. Res., 53:1328-1332 (1992).
Kramer et al., "Safety and Efficacy of an Attenuated Strain of Salmonella choleraesius for Vaccination of Swine," Amer. J. Vet. Res., 53:444-448 (1992).
Kramer and Wood, "Local and Systemic Immunity to Salmonella Choleraesius, Proceedings of the 91st Annual Meeting of the United States Animal Health Assn.," Salt Lake City, Utah 1987.
Smith, "The Immunization of Mice, Calves, and Pigs against Salmonella dublin and Salmonella cholera-suis Infections, " J. Hyg. Camb., 63:117-135 (1965).
Taira et al., Microbial Pathogenesis, 7:165-173 (1989).
Benjamin et al., Infection and Immunity, 51:872-878 (1986).
Nnalue et al., Infection and Immunity, 55:955-962 (1987).
Nnalue, "Mice Vaccinated With a Non-Virulent, Aromatic-Dependent Mutant of Salmonella Choleraesuis Die From Challenge With Its Virulent Parent But Survive Challenge With Salmonella typhimurium, J. Med Microbiol."31:225-233 (1990).
Quaife, "Unlocking its Deadly Grip", Swine Practitioner, pp. 4-7, Feb. 1992.
Edwards et al., Identification of Enterobacteriaceae (3rd edition), Burgess Publishing Co. Minneapolis, Minn., p. 154.
Supplementary European Search Report, Appln. No. EP 92 90 0047, Mar. 10, 1994.
File Server STN Karlsruhe, File Medline Abstract No. 83159793 & Infect. Immun. (1983 Feb.) 39 (2) 779-84 Collins et al. "Bactericidal Activity of Alveqlar and Peritoneal Macrophages Exposed in Vitro to Three Strains of Pasteurella Multocida" (Abstract).
File Server STN Karlisruhe, File Biosis Abstract No. 88:71320 & J. Exp. Med. 166(5). 1987. 1310-1328 Horwitz: "Characterization of Avirulent Mutant Legionella-Pneumophila That Survive But Do Not Multiply Within Human Monocytes" (Abstract).
Dadio Susan M.
Iowa State University Research Foundation
Knode Marian C.
LandOfFree
Live, avirulent Salmonella choleraesuis vaccine used for inducin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Live, avirulent Salmonella choleraesuis vaccine used for inducin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Live, avirulent Salmonella choleraesuis vaccine used for inducin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-738185