Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1988-01-27
1989-09-19
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Lymphokine
435235, 435237, 435236, 435948, A61K 39215
Patent
active
048679755
ABSTRACT:
The cold-adapted (ca) temperature-sensitive (ts) vaccine is prepared by serially passaging a suitably selected virus (e.g. Arkansas-type DPI strain) through a culture medium at a suboptimal replication temperature which is less than about 35.degree. C., e.g. 28.degree. C., and harvesting the live, cold-adapted mutant for formulation into dosage units of, for example, about 10.sup.3 to about 10.sup.5 EID.sub.50 /bird. The ca ts mutant is much less able to replicate at 40.degree.-42.degree. C. (internal avian body temperatures) than at the temperature of the bird's upper respiratory tract, which is below 40.degree. C. The vaccine can be administered by any of the usual techniques, including the spray technique. Vaccines of this invention appear to be very effective (immunogenic), but are also safe (non-pathogenic).
REFERENCES:
patent: Re31830 (1985-02-01), Apontoweil et al.
patent: 3907986 (1975-09-01), Zygraich et al.
patent: 3927208 (1975-12-01), Zygraich et al.
patent: 4053582 (1977-10-01), Sticki
patent: 4235876 (1980-11-01), Gits et al.
patent: 4357320 (1982-11-01), Apontoweil et al.
patent: 4481188 (1984-11-01), Apontoweil et al.
patent: 4500638 (1985-02-01), Apontoweil et al.
patent: 4554158 (1985-11-01), Russell
patent: 4559229 (1985-12-01), Page et al.
patent: 4751079 (1988-06-01), Burger et al.
M. S. Hofstad, Veterinary Medicine 51:464-468 (1956).
J. P. Delaplane et al., Rhode Island Agr. Expt. Station, Bulletin 284, pp. 4-20 (1941).
H. F. Maassab et al., Proc. Soc. Exptl. Bio. Med. 139:768-773 (1972).
H. F. Maassab, J. Immunol. 102:728-732 (1969).
J. Gelb et al., Avian Diseases 25:655-666 (1981).
J. Gelb et al., Avian Diseases 27:667-678 (1983).
J. Gelb et al., Avian Diseases 27:679-687 (1983).
Schain Howard E.
University of Delaware
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