Live attenuated newcastle disease virus vaccines and preparation

Drug – bio-affecting and body treating compositions – Lymphokine

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4352351, 435236, 435237, 435948, A61K 3912, C12N 700

Patent

active

052502988

ABSTRACT:
Novel live, cold-adapted temperature-sensitive (CaTs), attenuated Newcastle disease virus vaccines are provided which are effectively immunogenic and contain a mutant of a Hitchner B.sub.1 parent strain of Newcastle disease virus.

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Zygraich et al. in Potential as an Aerosol Vaccine of an Improved Newcastle Disease Vaccine Derived from the LaSota Strain-II. In Vivo Studies, ibid, 59-66.
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Samburg et al., Spray Vaccination of Chickens with an Experimental Vaccine Against Newcastle Disease, Avian Pathology, 6:251-258 (1977).
Kim et al., Administration of a Vaccine Prepared from the Australian V4 Strain of Newcastle Disease Virus by Aerosol and Drinking Water, Australian Veterinary Journal, 54, 486-489 (1978).
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Srinivasappa et al., Isolation of a Monoclonal Antibody with Specificity for Commonly Employed Vaccine Strains of Newcastle Disease Virus, Avian Diseases, 30:562-567 (1986).
Lana et al. in Characterization of a Battery of Monoclonal Antibodies for Differentiation of Newcastle Disease Virus and Pigeon Paramyxovirus-1 Strains, Avian Diseases 32:273-281 (1988).
R. P. Hanson, Chapter 20 of Isolation and Identification of Avian Pathogens, edited by Hitchner et al., American Association of Avian Pathologists, Arnold Printing Corporations, Ithaca, N.Y. 14850 (1975), pp. 166-168.
Gelb et al., Improved Respiratory Virus Vaccines for Broilers, Proceedings of the 23rd National Meeting on Poultry Health and Condemnations, Oct. 20 and 21, 1988.

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