Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2001-09-25
2009-02-24
Chen, Stacy B. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C424S209100, C435S235100
Reexamination Certificate
active
07494659
ABSTRACT:
The invention relates to a simple and efficient process for isolating viruses from various sources and for producing live attenuated influenza vaccines in a serum-free Vero cell culture under conditions where alterations in the surface antigens of the virus due to adpative selection are minimized or prevented. The process does not require purification of the virus-containing supernatant harvested from the cell culture nor post-incubation treatment of the viruses for HA activation. The invention further relates to influenza A and B master strain candidates and to vaccines made thereof.
REFERENCES:
patent: 5753489 (1998-05-01), Kistner et al.
patent: WO 99/64068 (1999-12-01), None
patent: WO 00/15251 (2000-03-01), None
O. Kistner et al.: “Development of a Mammalian Cell (Vero) Derived Candidate Influenza Virus Vaccine”, vol. 16, No. 9/10, 1998, pp. 960-968, XP002163941, see especially p. 961, paragraph bridging cols. 1 and 2.
O. Kistner et al.: “Development of a Vero Cell Derived Influenza Whole Virus Vaccine”, Dev. Biol. Stand., vol. 98, 1999, pp. 101-110, XP000909542.
O.W. Merten et al.: “Production of Influenza Virus in Serum-free Mammalian cell Cultures”, Dev. Biol. Stand., vol. 98, 1999, pp. 23-37, XP000990517.
N. Kaverin et al.: “Impairment of Multicycle Influenza Growth in Vero (WHO) Cells by Loss of Trypsin Activity”, J. Virol., vol. 69, No. 4, 1995, pp. 2700-2703, XP002163942, cited in the application.
Egorov Andre
Ferko Boris
Katinger Dietmar
Katinger Hermann
Romanova Julia
Chen Stacy B.
Ostrolenk Faber Gerb & Soffen, LLP
Polymun Scientific Immunbiologische Forschung GmbH
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