Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2005-05-23
2008-11-18
Mosher, Mary E (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C435S235100, C435S236000, C536S023720
Reexamination Certificate
active
07452542
ABSTRACT:
The present invention is directed live, attenuated coronavirus vaccines. The vaccine comprises a viral genome encoding a p59 protein having at mutation at a specific tyrosine residue, and may include other attenuating mutations. Such viruses show reduced growth and pathogenicity in vivo.
REFERENCES:
Enjuanes et al. Current Topics in Microbiology and Immunology 287: 161-197, 2005.
Thiel et al. Current Topics in Microbiology and Immunology 287: 199-227, 2005.
Masters et al. Current Topics in Microbiology and Immunology 287: 133-159. 2005.
Gorbalenya et al. Virus Research 117:17-37, 2006.
Cavanagh. Avian Pathology 32(6):567-582, 2003.
Saif. “Animal Coronavirus Vaccines: Lessons for SARS.” Developments in Biologicals 119:129-140, 2004.
Index of Viruses—Coronaviridae (2006). In: ICTVdB—The Universal Virus Database, version 4. Büchen-Osmond, C (Ed), Columbia University, New York, USA. <<http://www.ncbi.nlm.nih.gov/ICTVdb/lctv/fs—index.htm>> Downloaded Aug. 1, 2008.
Baker et al., “Identification of the catalytic sites of a papain-like cysteine proteinase of murine coronavirus,”J. Virol., 67:6056-6063, 1993.
Bonilla et al., “Characterization of a second cleavage site and demonstration of activity in trans by the papain-like proteinase of the murine coronavirus mouse hepatitis virus strain A59,”J. Virol., 71:900-909, 1997.
Bonilla et al., “Characterization of the Leader Papain-like Proteinase of MHV-A59: Identification of a New in Vitro Cleavage Site,”Virology, 209:489-497, 1995.
Boursnell et al., “Completion of the sequence of the genome of the coronavirus avian infectious bronchitis virus,”J. Gen. Virol., 68:57-77, 1987.
Chouljenko et al., “Comparison of genomic and predicted amino acid sequences of respiratory and enteric bovine coronaviruses isolated from the same animal with fatal shipping pneumonia,”J. Gen. Virol., 82:2927-2933, 2001.
Curtis et al., “Heterologous gene expression from transmissible gastroenteritis virus replicon particles,”J. Virol., 76:1422-1434, 2002.
Dong and Baker, “Determinants of the p28 Cleavage Site Recognized by the First Papain-like Cysteine Proteinase of Murin Coronavirus,”Virology, 204:541-549, 1994.
Eleouet et al., “Complete Sequence (20 Kilobases) of the Polyprotein-Encoding Gene 1 of Transmissible Gastroenteritis Virus,”Virology, 206:817-822, 1995.
Yoo and Pei, “Full-length genomic sequence of bovine coronavirus (31 kb). Completion of the open reading frame 1a/1b sequences,”Adv. Exp. Med. Biol., 494:73-76, 2001.
Yount et al., “Strategy for systematic assembly of large RNA and DNA genomes: transmissible gastroenteritis virus model,”J. Virol., 74:10600-10611, 2000.
Yount et al., “Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59,”J. Virol., 76:11065-11078, 2002.
Ziebuhr et al., “The autocatalytic release of a putative RNA virus transcription factor from its polyprotein precursor involves two paralogous papain-like proteases that cleave the same peptide bond,”J. Biol. Chem., 276:33220-33232, 2001.
Genbank Accession No. AY274119, (2004).
Genbank Accession No. AY278491, (2003).
Genbank Accession No. AY278554, (2003).
Genbank Accession No. NC—001451, (2005).
Genbank Accession No. NC—001846, (2006).
Genbank Accession No. NC—002306, (2006).
Genbank Accession No. NC—002645, (2004).
Genbank Accession No. NC—003045, (2005).
Herold et al., “A human RNA viral cysteine proteinase that depends upon a unique Zn2+−binding finger connecting the two domains of a papain-like fold,”J. Biol. Chem., 274:14918-14925, 1999.
Herold et al., “Nucleotide Sequence of the Human Coronavirus 229E RNA Polymerase Locus,”Virology, 195:680-691, 1993.
Hughes et al., “Identification of the murine coronavirus p. 28 cleavage site,”J. Virol., 69:809-813, 1995.
Kanjanahaluethai and Baker, “Identification of mouse hepatitis virus papain-like proteinase 2 activity,”J. Virol., 74:7911-7921, 2000.
Kanjanahaluethai and Baker., “Processing of the replicase of murine coronavirus: papain-like proteinase 2 (PLP2) acts to generate p. 150 and p. 44,”Adv. Exp. Med. Biol., 494:267-273, 2001.
Lee et al., “The Complete Sequence (22 Kilobases) of Murine Coronavirus Gene 1 Encoding the Putative Proteases and RNA Polymerase,”Virology, 180:567-582, 1991.
Schaad et al., “Genetics of Mouse Hepatitis Virus Transcription: Identification of Cistrons which May Function in Positive and Negative Strand RNA Synthesis,”Virology, 177:634-645, 1990.
Tijms et al., “A zinc finger-containing papain-like protease couples subgenomic mRNA synthesis to genome translation in a positive-stranded RNA virus,”Proc. Natl. Acad. Sci. USA, 98:1889-1894, 2001.
Fulbright & Jaworski
Mosher Mary E
Vanderbilt University
LandOfFree
Live attenuated coronavirus vaccines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Live attenuated coronavirus vaccines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Live attenuated coronavirus vaccines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4025836