Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1976-03-16
1978-09-05
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
2603436, C07C 5904
Patent
active
041119878
ABSTRACT:
A process for the resolution of optical isomers of racemic lithium pantoate by selective crystallization from a solution in methanol, ethanol, or other polar solvents, or by electrostatic separation. The optical isomers can be readily converted to optically active pantolactones which are the starting material for the preparation of optically active pantothenic acid and its salt and pantothenyl alcohol. One of the two optical isomers of each of these compounds possesses vitamin activity. The unwanted or inactive optical isomer of lithium pantoate as such is thermally stable and can be racemized by heating in the presence of a basic reacting compound at a temperature between 120.degree. and 180.degree. C to produce a racemic mixture which can then be subjected directly to resolution without conversion to some other derivative in accordance with the processes of the present invention to produce the desired or active optical isomer.
REFERENCES:
patent: 2739157 (1956-03-01), Hammond
Noller, C. R. Chem. of Organic Comp. 2nd ed., p. 345.
Bamberg Wolfgang
Schmidt Joachim
Schneider Wolfgang
Weigelt Christian
Killos Paul J.
Striker Michael J.
V E B Jenapharm
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