LIR-9, a novel leukocyte immunoglobulin-like receptor

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

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07875703

ABSTRACT:
A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridizes to defined nucleotide sequences, processes for producing polypeptides of the LIR family, and specific antibodies directed against LIR polypeptides. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.

REFERENCES:
patent: WO 98/09638 (1998-03-01), None
patent: WO 98/24906 (1998-06-01), None
patent: WO 98/31806 (1998-07-01), None
patent: WO 98/48017 (1998-10-01), None
Mikayama et al. PNAS, 1993. 90: 10056-10060.
Burgess et al J Cell Biol. 111:2129-2138, 1990.
Metzler et al. (Nature Structural Biol. 1997; 4:527-531.
Skolnick et al. (Trends in Biotech. 2000; 18(1):34-39.
Allan et al., “Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells,”J. Exp. Med. 189(7):1149-1155, 1999.
Arm et al., “Molecular cloning of gp49, a cell-surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily,”J. Biol. Chem. 266(24):15966-15973, 1991.
Arm et al., “Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor,”J. Immunol. 159(5):2342-2349, 1997.
Banham et al., “Identification of the CD85 antigen as ILT2, an inhibitory MHC class I receptor of the immunoglobulin superfamily,”J. Leukoc. Biol. 65:841-845, 1999.
Berg et al., “NILR-1, a novel immunoglobulin-like receptor expressed by neutrophilic granulocytes, is encoded by a leukocyte receptor gene complex on rat chromosome 1,”Eur. J. Immonol. 29:2000-2006, 1999.
Biassoni et al., “The human leukocyte antigen (HLA)-C-specific ‘activatory’ or ‘inhibitory’ natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions,”J. Exp. Med. 183:645-650, Feb. 1996.
Bléry et al., “Reconstituted killer cell inhibitory receptors for major histocompatibility complex class 1 molecules control mast cell activation induced via immunoreceptor tyrosine-based activation motifs,”J. Biol. Chem. 272(14):8989-8996, 1997.
Bléry et al., “The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1,”Proc. Natl. Acad. Sci. USA95:2446-2451, 1998.
Borges et al., “A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules,”J. Immunol. 159 (11):5192-5196, 1997.
Borges et al., “Interactions of LIRs, a family of immunoreceptors expressed in myeloid and lymphoid cells, with viral and cellular MHC clas I antigens,”Curr. Top. Microbiol. Immunol. 244:123-136, 1999.
Brooke et al., “Cloning of two members of the SIRPα family of protein tyrosine phosphatase binding proteins in cattle that are expressed on monocytes and a subpopulation of dendritic cells and which mediate binding to CD4 T cells,”Eur. J. Immunol. 28:1-11, 1998.
Burshtyn et al., “Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor,”Immunity4:77-85, Jan. 1996.
Burshtyn et al., “Conserved residues amino-terminal of cytoplasmic tyrosines contribute to the SHP-1-mediated inhibitory function of killer cell Ig-like receptors,”J. Immunol. 162:897-902, 1999.
Castells et al., “Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49,”J. Biol. Chem. 269(11):8393-8401, 1994.
Cella et al., “A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing,”J. Exp. Med. 185(10): 1743-1751, May 1997.
Chapman et al., “The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18,”Immunity11:603-613, 1999.
Colonna et al., “Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells,”Science268:405-408, Apr. 1995.
Colonna et al., “Cutting edge: human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules,”J. Immunol.160:3096-3100, 1998.
Colonna et al., “A novel family of Ig-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells,”J. Leukoc. Biol.66:375-381, 1999.
Colonna et al., “Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells,”J. Leukoc. Biol.66:718-722, 1999.
Cosman et al., “A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules,”Immunity7:273-282, 1997.
Cosman et al., “Human cytomegalovirus, MHC class I and inhibitory signalling receptors: more questions than answers,”Immunol. Rev.168:177-185, 1999.
Fanger et al., “The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signalling in monocytes,”Eur. J. Immunol.28:3423-3434, 1998.
Fanger et al., “The leukocyte immunoglobulin-like receptors (LIRs): a new family of immune regulators,”J. Leukoc. Biol.66:231-236, 1999.
Fournier et al., “FDF03, a novel Ig-like transmembrane protein with tyrosine-based motifs expressed by human dendritic and myeloid cells,”J. Leukoc. Biol. (suppl 2):B47, Sep. 1998.
Fry et al., “Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C,”J. Exp. Med.184:295-300, Jul. 1996.
Hayami et al., “Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors,”J. Biol. Chem.272:7320-7327, Mar. 1997.
Imboden, J. “Innate immunity: Turning off natural killers,”Curr. Biol. 6#9:1070-1072, 1996.
Kadowaki et al., “Engagement of new KIR-like receptors KLM promotes maturation of human dendritic cells,”J. Leukoc. Biol. (suppl 2):B9, Sep. 1998.
Katz et al., “Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE,”Proc. Natl. Acad. Sci. USA93:10809-10814, Oct. 1996.
Kubagawa et al., “A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells,”Proc. Natl. Acad. Sci. USA94:5261-5266, May 1997.
Kubagawa et al., “Biochemical nature and cellular distribution of the paired immunoglobulin-like receptors, PIR-A and PIR-B,”J. Exp. Med.189(2):309-317, 1999.
Kuroiwa et al., “Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene,”J. Biol. Chem.273(2):1070-1074, 1998.
Lanier et al., “Inhibitory MHC class I receptors on NK cells and T cells,”Immunol. Today: Feb. 1996.
Lanier, L., “Natural killer cell receptors and MHC class I interactions,” Curr. Opin. Immunol. 9(1):126-131,1997.
Maeda et al., “Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal,”J. Exp. Med.187(8):1355-1360, 1998.
Maeda et al., “Paired immunoglobulin-like receptor (PIR)-A is involved in activating mast cells through its association with Fc receptorγ chain,”J. Exp. Med.188(5):991-995, 1998.
Menaa et al., “Plenary Poster: T082. Upregulate

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