Liquisolid systems and methods of preparing same

Details Liquisolid systems and methods of preparing same Liquisolid systems and methods of preparing same

1997-10-01

1999-10-19

Krass, Frederick

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424456, 424457, 424458, 424459, 424461, 424462, 424464, 424465, 424468, 424489, 424490, 424493, 424494, 424497, 424501, A61K 920

Patent

active

059685506

ABSTRACT:
Liquisolid systems are acceptably flowing and compressible powdered forms of liquid medications. According to the concept of liquisolid systems, liquid lipophilic drugs, or water-insoluble solid drugs dissolved in suitable non-volatile solvents, may be converted into free-flowing and readily compressible powders by a simple admixture with selected powder excipients referred to as the carrier and coating materials. Various grades of microcrystalline or amorphous cellulose may be used as carriers, whereas very fine particle size silica powders may be used as coating materials. Based on the theory that the carrier and coating materials can retain only certain amounts of liquid and at the same time maintain acceptable flow and compression properties, a new formulation-mathematical model is provided to calculate the optimum quantities of carrier and coating materials required to yield acceptably flowing and compressible liquid/powder admixtures.

REFERENCES:
"Powdered Solution Technology: Principles and Mechanism", Pharm. Res. 9: 1351-1368, Apr. 1992.
"Use of Powdered Solutions to Improve the Dissolution Rate of Polythiazide Tablets", Drug. Dev. Ind. Pharm. 16: 769-777, May 1990.

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