Liquiflash particles and method of making same

Details Liquiflash particles and method of making same Liquiflash particles and method of making same

1994-10-28

1997-11-04

Mullis, Jeffrey

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424490, 424493, 426512, 426515, A61K 914

Patent

active

056837208

ABSTRACT:
The present invention is a method of making discrete particles by subjecting an organic feedstock to liquiflash conditions whereby the feedstock is transformed instantaneously from solid to liquiform to solid. Liquiform is a transient condition wherein the feedstock has substantially unimpeded internal flow. Shear force is imparted to the liquiform feedstock in an amount sufficient to separate tiny masses of feedstock. The tiny masses solidify as discretized particles. The present invention also includes unique products resulting from the process, e.g., a monodispersed microsphere product and coated particles prepared therefrom.

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FMC Corporation, Pharmaceutical Division, Product Information Sheets on AviSphere.SM. System, AviSpheres.TM., Drug Loaded Spheres, Copyright 1993 FMC Corporation.

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