Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Calorimeter
Patent
1994-04-08
1996-05-14
Warden, Jill
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Calorimeter
422 57, 422 58, 422 61, 435 792, 436518, G01N 3122
Patent
active
055164889
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
There is considerable commercial interest in simple, disposable, self-contained devices for performing biochemical diagnostic assays in extra-laboratory situations. Ideally such devices should avoid any need for complex manual procedures, such as a timed sequence of reagent additions to an analyte, and so be suitable for use by lay persons.
According to Patent Specification WO90/11519 such devices can be of a kind comprising first and second liquid flow channels of porous materials leading from a respective pair of channel ends to a common site, which channels are operable to transfer liquid by capillary flow to the common site in sequentially timed manner following simultaneous application of the liquid to the pair of channel ends.
However, while Specification WO90/11519 describes a variety of particular devices of this kind, they are largely suited to carrying out a single analytical procedure. In contrast there are many situations in which it is desirable to perform plural procedures simultaneously and there would be advantage in a multiple device of integrated form making available such a performance.
SUMMARY OF THE INVENTION
The present invention provides an improved device of the above-mentioned kind which is particularly, but not exclusively, of the subsequently mentioned multiple integrated form.
According to the present invention, the improved device has the first and second channels formed by respective mutually superposed layers of porous material separated by a liquid impermeable barrier except for at least one selected area over which the layers are engaged for liquid flow therebetween.
In multiple integrated form the improved device has a plurality of first and second channel pairs formed by common respective porous material layers.
BRIEF DESCRIPTION OF THE DRAWINGS
The invention is further described below, by way of example, with reference to the accompanying drawings, in which:
FIGS. 1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h, 2a, 2b, 3a, 3b, 4a, 4b, 4c, 5a, 5b, and 5c respectively illustrate different forms of device which accord with the invention and/or are explanatory of the operation of such a device.
DETAILED DESCRIPTION OF THE INVENTION
The device of FIG. 1 is of generally rectangular sheet overall form, denoted at 10, and is respectively illustrated in front, rear and side views at (a), (b) and (c).
The device has four pairs of first channels 11 and second channels 12 respectively formed by front and rear layers of porous material, which layers are separated by a liquid impervious membrane 13.
The first channels 11 commence from one end of the device in a common portion 11a of narrowed tortuous form. Thereafter the channels assume a broadened rectilinear form having successive portions 11b,c and d. The portion 11b has partway therealong a liquid impermeable bar 14 extending transversely across its central region and portion 11c has three uniformly spaced, parallel, liquid impermeable bars 15 extending therealong to define four discrete first channel portions. Each of these last portions has located successively therealong two reagent regions R2 and R1 and a sample application region S.
The membrane 13 Is In two portions 13a and b. The first portion 13a extends against first channel portions 11a,b and c up to a point beyond reagent zones R2, but not as far as reagent zones R1. The second membrane portion 13b extends against first channel portions 11c and d from a point just before reagent zones R1 in the former, but without engaging the first membrane portion. There is accordingly a transverse gap 16 between the membrane portions.
The second channels 12 commence from the same end of the device as the first channels in a common portion 12a of narrowed rectilinear form. Thereafter the channels assume a broadened rectilinear form having successive portions 12b and c. These last portions are similar to the first channel portions 11b and c and have respective bars 17 and 18. However, the discrete second channel portions 12c terminate at the gap 16 where they resp
REFERENCES:
patent: 4622207 (1986-11-01), Wang
patent: 4855240 (1989-08-01), Rosenstein et al.
patent: 4960691 (1990-10-01), Gordon et al.
patent: 5079142 (1992-01-01), Coleman et al.
Bunce et al. "Disposable Analytical Devices Permitting Automatic, Timed Sequential Delivery of Multiple Reagents" Analytica Chimica Acta v. 249 (1991) pp. 263-269.
Bunce Roger A.
Starsmore Stephen J.
British Technology Group Limited
Ludlow Jan M.
Warden Jill
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