Liquid phase process for the preparation of GnRH peptides

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides

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530344, 530345, 530333, 530328, 514 15, C07K 706

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active

059773022

ABSTRACT:
A liquid phase process for preparing GnRH peptide analogs of the formula:

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J. Med. Chem. 1991, 34, pp. 2395-2402 Novel Gonadotropin-Releasing Hormone Antagonists: Peptides Incorporating Modified N-Cyanoguanidino Moieties.
Biochemical and Biophysical Research Communications vol. 176, No. 1, 1991, Apr. 15, 1991 pp. 406-412 Gonadotropin Releasing Hormone Antogonists: Novel Structures Incorporating N-Cyano Modified Guanidine Moieties.
J. Med. Chem. 1986, 29, pp. 1846-1851 New Effective Gonadotropin Releasing Hormone Antagonists with Minimal Ppotency for Histamine Release In Vitro.
J. Am. Chem. Soc. 1990, 112, pp. 9624-9626 General Method for Incorporation of Modified N-Cyanoguanidino Moletities on Selected Amino Functions During Solid Phase Peptide Synthesis.
J. Med. Chem. 1995, 38 pp. 2649-2662 Gonadotropin-Releasing Hormone Antagonists: Novel Members of the Azaline B Family.

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