Liquid phase preparation of 2-H-2-oxazolines and 2-substituted-2

Details Liquid phase preparation of 2-H-2-oxazolines and 2-substituted-2 Liquid phase preparation of 2-H-2-oxazolines and 2-substituted-2

1982-09-07

1984-04-17

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20720

Patent

active

044436114

ABSTRACT:
2-H-2-Oxazolines are prepared by contacting in liquid phase a N-(.beta.-hydroxyalkyl)formamide with a small but catalytic amount of an inorganic zinc salt at elevated temperatures. Similarly, 2-substituted-2-oxazolines are prepared by contacting N-(2-hydroxyalkyl)carboxamides with a small but catalytic amount of an inorganic zinc salt. As an example, 2-H-2-oxazoline was prepared in approximately 72 percent yield by warming a mixture of N-(.beta.-hydroxyethyl)formamide with a catalytic amount of zinc chloride at a temperature of from 180.degree. C. to 185.degree. C./50 mm Hg for 2.2 hours. In this reaction, the desired oxazoline product was recovered as a codistillate with water during the course of the reaction.

REFERENCES:
patent: 4035309 (1977-07-01), Brois

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