Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 11 to 14 amino acid residues in defined sequence
Patent
1997-06-25
2000-01-11
Woodward, Michael P.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
11 to 14 amino acid residues in defined sequence
530328, 530329, 530330, 530333, 530335, 530336, 530338, 530339, C07K 102, C07K 108, C07K 110, C07K 1400
Patent
active
060137649
ABSTRACT:
The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu.sub.4).sub.4 -Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the .alpha.-carbon.
REFERENCES:
patent: 4430262 (1984-02-01), Engels et al.
patent: 4581168 (1986-04-01), Diaz et al.
patent: 4603209 (1986-07-01), Tsien et al.
patent: 4607030 (1986-08-01), Englert et al.
patent: 5164369 (1992-11-01), Cochrane et al.
patent: 5260273 (1993-11-01), Cochrane et al.
patent: 5407914 (1995-04-01), Cochrane et al.
patent: 5599926 (1997-02-01), Still et al.
Synthesis and Characterization of Some Polyurethane Ionomers, H.S. Esgboh et al., Polymer, 1982, vol. 23, Jul. 1982, pp. 1167-1171.
Phospholipids Chiral at Phosphorus: Synthesis of Dioteoylthiophosphatidylcholine and Stereospecificity of Lecithin-Cholesterol Acyltransferase, Theresa Rosario-Jansen et al. Biorganic Chemistry 18, 179-184 (1990).
An Improved Method for the Synthesis of Radiolabeled MCN5652 via Thioester Precursors, Makiko Suehiro et al. Nucl. Med. Biol. vol. 22, No., 4. pp. 543-545, 1995.
International Search Report application No. PCT/US97/12163 dated Dec. 19, 1997 with references.
Lloyd-Williams, P. et al. Convergent solid-phase peptide synthesis Tetrahedron 49(48):11065-11133. (pages 11087-11089 provided), 1993.
Carey, F.A., Organic Chemistry, McGraw-Hill, New York, pp. 793-798, 1987.
Abdel-Magid Ahmed F.
Eggmann Urs
Maryanoff Cynthia Anne
Thaler Adrian
Villani Frank J.
Dow Kenneth J.
Gupta Anish
Ortho Pharmaceutical Corp.
Woodward Michael P.
LandOfFree
Liquid phase peptide synthesis of KL-4 pulmonary surfactant does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Liquid phase peptide synthesis of KL-4 pulmonary surfactant, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Liquid phase peptide synthesis of KL-4 pulmonary surfactant will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1463243