Liquid interface configurations for automated patch clamp...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...

Reexamination Certificate

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C435S006120

Reexamination Certificate

active

10305828

ABSTRACT:
A method of automatically conducting patch clamp testing is provided wherein a liquid interface is utilized. The liquid interface is defined in a liquid suspension between layers of distinct densities such that cells introduced into the liquid suspension float towards the interface. Thus, the cells are locatable relative to the interface.

REFERENCES:
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Tie et al., British Journal of Pharmacology 130:1967-1975 (2000).
Snyder et al., Pflugers Archiv-European Journal of Physiology, (Aug. 1999) vol. 438, No. 3, pp. 405-411.
Varming, Neuropharmacology 38:1875-1881 (1999).
Egee et al., Journal of Physiology 504(1):57-63 (1997).

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