Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1997-03-07
1999-02-16
Saunders, David
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
5303905, A61K 39395
Patent
active
058717366
ABSTRACT:
Immunoglobulin preparations, particularly liquid preparations of immunogllin G for intravenous infusion, are stabilized against dimer formation by the addition of one or more amphiphilic stabilizers. Preferred amphiphilic stabilizers are nicotinic acid derivatives, particularly nicotinamide, and naturally-occurring .alpha.-amino acids having a lipophilic side chain, for example phenylalanine, proline, leucine and isoleucine.
REFERENCES:
patent: 4360457 (1982-11-01), Ono et al.
Derwent AN 85-193554 (1985).
Derwent AN 93-261569 (1993).
Bruegger Rene
Gennari Katharina
Hodler Gerhard
Wuest Bernard
Furman Diane E.
Pfeiffer Hesna J.
Red Cross Foundation Central Laboratory Blood Transfusion Servic
Saunders David
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