Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-04-14
1999-07-27
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 8, 514 12, 514800, 530398, 530399, 424452, 424418, 424455, A01N 3718, A61K 3816
Patent
active
059290285
ABSTRACT:
The invention concerns a liquid gonadotropin-containing formulation characterised in that the formulation comprises a gonadotropin and stabilising amounts of a polycarboxylic acid or a salt thereof and of a thioether compound. The particular proteins (e.g. LH, TSH, FSH, or HCG) are in admixture with the particular stabilizers in an aqueous solution. The preparations contain a sufficient amount of the polycarboxylic acid or a salt thereof, preferably sodium citrate, and a sufficient amount of the thioether compound, preferably methionine, to stabilize the protein. The preparations preferably also include a nonreducing disaccharide like sucrose, and a non-ionic surfactant.
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Schroeder, W.; "Methods for Partial Hydrolysis of the Polypeptide Chain" in The Primary Structure of Proteins, Harper & Row:NewYork, 1968, Chapter 9.
Skrabanja Arnold Titus Philip
van den Oetelaar Petrus Johannes Maria
Akzo Nobel N.V.
Gormley Mary E.
Jameison Fabian A.
Tsang Cecilia J.
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