Liquid gonadotropin containing formulations

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 8, 514 12, 514800, 530398, 530399, 424452, 424418, 424455, A01N 3718, A61K 3816

Patent

active

059290285

ABSTRACT:
The invention concerns a liquid gonadotropin-containing formulation characterised in that the formulation comprises a gonadotropin and stabilising amounts of a polycarboxylic acid or a salt thereof and of a thioether compound. The particular proteins (e.g. LH, TSH, FSH, or HCG) are in admixture with the particular stabilizers in an aqueous solution. The preparations contain a sufficient amount of the polycarboxylic acid or a salt thereof, preferably sodium citrate, and a sufficient amount of the thioether compound, preferably methionine, to stabilize the protein. The preparations preferably also include a nonreducing disaccharide like sucrose, and a non-ionic surfactant.

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patent: 5114948 (1992-05-01), Conine et al.
patent: 5272135 (1993-12-01), Takruri et al.
patent: 5338835 (1994-08-01), Boime et al.
patent: 5384132 (1995-01-01), De Meere et al.
patent: 5650390 (1997-07-01), Samaritani et al.
patent: 5730969 (1998-03-01), Hora et al.
patent: 5767067 (1998-06-01), Arpaia et al.
Schroeder, W.; "Methods for Partial Hydrolysis of the Polypeptide Chain" in The Primary Structure of Proteins, Harper & Row:NewYork, 1968, Chapter 9.

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