Liquid formulations for proteinic pharmaceuticals

Details Liquid formulations for proteinic pharmaceuticals Liquid formulations for proteinic pharmaceuticals

1995-05-16

1997-08-05

Hulina, Amy

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

424434, 424455, 514946, 514947, A61K 3800

Patent

active

056539878

ABSTRACT:
A liquid pharmaceutical agent formulation suitable for oral or nasal delivery comprises a proteinic pharmaceutical agent, water and at least two absorption enhancing compounds. The absorption enhancing compounds are selected from sodium salicylate, sodium lauryl sulphate, disodium ethylenediaminetetraacetic acid (disodium EDTA), oleic acid, linoleic acid, monoolein, lecithin, lysolecithin, deoxycholate, sodium deoxycholate, chenodeoxycholate, taurodeoxycholate, glycochenodeoxycholate, polyoxyethylene X-lauryl ether wherein X is from 9 to 20, sodium tauro-24, 25-dihydrofusidate, polyoxyethylene ether, polyoxyethylene sorbitan esters, p-t-octylphenoxypolyoxyethylene, N-lauryl-.beta.-D-maltopyranoside, 1-dodecylazacycloheptane-2-azone and phospholipids, wherein the amount of each of the absorption enhancing compounds is present in a concentration of from 1 to 10 wt./wt. % of the total formulation. Preferably each of the absorption enhancing compounds is present in a concentration of from 1.5 to 3.5 wt./wt. % The formulation is particulary adapted to oral delivery of insulin.

REFERENCES:
patent: 4690952 (1987-09-01), Kagatani et al.
patent: 4900730 (1990-02-01), Miyauchi
patent: 5206219 (1993-04-01), Desai
patent: 5346701 (1994-09-01), Heiber et al.
patent: 5447729 (1995-09-01), Belenduik et al.
patent: 5482706 (1996-01-01), Igari et al.

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