Compositions – Compositions containing a single chemical reactant or plural... – Organic reactant
Patent
1993-10-26
1995-06-06
Lieberman, Paul
Compositions
Compositions containing a single chemical reactant or plural...
Organic reactant
435188, 25217412, 252DIG12, C11D 3386
Patent
active
054220300
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
This invention relates to liquid detergent compositions comprising anionic or nonionic surfactant, proteolytic enzyme, second enzyme, and an aromatic borate ester.
BACKGROUND OF THE INVENTION
A commonly encountered problem with protease-containing liquid detergents is the degradation of second enzymes in the composition by the proteolytic enzyme. The stability of the second enzyme upon storage in product and its effect on cleaning are impaired by the proteolytic enzyme.
Boric acid and boronic acids are known to reversibly inhibit proteolytic enzymes. A discussion of the inhibition of one serine protease, subtilisin, by boronic acid is provided in Philipp, M. and Bender, M. L., "Kinetics of Subtilisin and Thiosubtilisin", Molecular & Cellular Biochemistry, vol. 51, pp. 5-32 (1983).
One type of boronic acid, peptide boronic acid, is discussed as an inhibitor of trypsin-like serine proteases, especially in pharmaceuticals, in European Patent Application 0 293 881, Kettner et al., published Dec. 7, 1988.
German Patent 3 918 761, published Jun. 28, 1990 discloses liquid enzyme concentrate which is said to be usable as a raw material solution for making liquid detergents and the like. The concentrate contains hydrolase, propylene glycol and boric acid or its salt.
U.S. Pat. No. 4,537,707, issued Aug. 27, 1985 describes heavy duty liquid detergents containing artionic surfactants, fatty acid, builder, proteolytic enzyme, boric acid, calcium ions and sodium formate. The combination of boric acid and sodium formate is claimed to provide improved proteolytic enzyme stability in this composition, especially in the presence of a polyol. These compositions are free of lipase.
European Patent Application 0 080 223, published Jun. 1, 1983 describes detergent compositions containing a polyfunctional amino compound or a polyol together with a reducing alkali metal salt.
Similarly in GB 2 079 305, published Jan. 20, 1982, it is disclosed that enhanced enzyme stability can be obtained in a built liquid detergent by inclusion of boric acid, a polyol in the ratio of polyol to boric acid more than 1:1, and a cross-linked polyacrylate polymer. These compositions contain no lipase.
In European Application 0 381 262, Aronson et el., published Aug. 8, 1990, mixtures of proteolytic and lipolytic enzymes in a liquid medium have been disclosed. The stability of lipase is claimed to be improved by the addition of boron compound and a polyol having vicinal hydroxyl groups.
It has now been found that certain aromatic borate esters are especially effective in reversibly inhibiting protease, in a HDL which also comprises detergency ingredients and a second enzyme.
Upon dilution, such as under typical wash conditions, the proteolytic enzyme is no longer inhibited and can function (e.g. to remove protease-sensitive stains from fabrics in the wash).
SUMMARY OF THE INVENTION
The present invention relates to a liquid detergent composition containing:
a. an aromatic borate ester formed by the complexation of boric acid with an aromatic reagent of the structure: ##STR1## Wherein: X is OH, SH, or NH.sub.2 ; ##STR2## each Z is H or a substituted or unsubstituted C.sub.1 -C.sub.6 alkyl, alkenyl, alkynyl or an aryl chain, OH or --O--R, wherein R is a C.sub.1 -C.sub.6 alkyl chain, or an electron withdrawing group such as CN, NO.sub.2 CHO, SO.sub.3 H, COOR wherein R is H or a C.sub.1 -C.sub.6 alkyl chain;
b. from about 0.0001 to 1% of active proteolytic enzyme;
c. a performance-enhancing amount of a detergent-compatible second enzyme;
d. from about 1 to 80 weight % of anionic or nonionic surfactant.
DESCRIPTION OF THE INVENTION
The present liquid detergent compositions contain certain essential ingredients: (a) an aromatic borate ester formed by the complexation of an aromatic reagent described herein after with boric acid or its derivatives; (b) proteolytic enzyme; (c) detergent-compatible second enzyme; (d) anionic and/or nonionic detersive surfactant.
These compositions will most commonly be used for cleaning of laun
REFERENCES:
patent: 3912595 (1975-10-01), Philipp et al.
patent: 4261868 (1981-04-01), Hora et al.
patent: 4537706 (1985-08-01), Severson, Jr. et al.
patent: 4537707 (1985-08-01), Severson, Jr. et al.
patent: 4670179 (1987-06-01), Inamorato et al.
patent: 4842769 (1989-06-01), Shulman
patent: 5030378 (1991-07-01), Venegas
patent: 5039446 (1991-08-01), Estell et al.
patent: 5089163 (1992-02-01), Aronson et al.
Lenoir Pierre M. A.
Panandiker Rajan K.
Thoen Christiaan A. J. K.
Allen George W.
Fries Kery A.
Lieberman Paul
Reed T. David
The Procter & Gamble & Company
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