Cleaning compositions for solid surfaces – auxiliary compositions – Cleaning compositions or processes of preparing – For cleaning a specific substrate or removing a specific...
Patent
1999-05-27
2000-12-19
Fries, Kery
Cleaning compositions for solid surfaces, auxiliary compositions
Cleaning compositions or processes of preparing
For cleaning a specific substrate or removing a specific...
510321, 510226, 510235, 510300, 510337, 510339, C11D 3386
Patent
active
061627836
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
This invention relates to liquid detergent compositions containing enzymes. More specifically, this invention pertains to liquid detergent compositions containing a detersive surfactant, a proteolytic enzyme, and a peptide protease inhibitor selected from the group consisting of peptide aldehydes and peptide trifluromethyl ketones.
BACKGROUND OF THE INVENTION
Protease-containing liquid aqueous detergents are well-known, especially in the context of laundry washing. A commonly encountered problem in such protease-containing liquid aqueous detergents is the degradation phenomenon by the proteolytic enzyme of second enzymes in the composition, such as amylase, lipase, and cellulase, or on the protease itself. As a result, the stability of the second enzyme or the protease itself in the detergent composition is affected and the detergent composition consequently performs less well.
In response to this problem, it has been proposed to use various protease inhibitors or stabilizers. For instance, various references have proposed the use of the following compounds to aid in the stabilization of enzymes: benzamidine hydrochloride, lower aliphatic alcohols or carboxylic acids, mixtures of a polyol and a boron compound, aromatic borate esters, and calcium, particularly calcium formate. Recently, it was discovered that certain peptide aldehydes and peptide trifluromethyl ketones act to stabilize protease enzyme.
Although these compounds have been used to varying success in liquid detergents, they are not free of problems. For example certain peptide aldehydes can be rather expensive and create complexities for the formulators, especially for liquid detergents. Other inhibitors such as calcium and boric acids are less expensive but do not stabilize enzymes as well as peptide aldehydes. It is thus an object of the present invention to provide alternate peptide aldehydes and trifluromethyl ketone protease inhibitors which are effective and suitable for use in a liquid detergent compositions.
BACKGROUND ART
It has been proposed to use various protease inhibitors or stabilizers. For instance, U.S. Pat. No. 4,566,985 proposes to use benzamidine hydrochloride; EP 376 705 proposes to use lower aliphatic alcohols or carboxylic acids; EP 381 262 proposes to use a mixture of a polyol and a boron compound; and EP 91870072.5 proposes to use aromatic borate esters. See also U.S. Pat. No. 5,030,378 issued Jul. 9, 1991. Also see U.S. Pat. No. 4,261,868; U.S. Pat. No. 4,404,115; U.S. Pat. No. 4,318,818; and EP 130,756.
The use of peptide derivatives for the inhibition of proteins appears to have been disclosed in therapeutic applications. EP 293 881 discloses the use of peptide boronic acids as inhibitors of trypsin-like serine proteases. EP 185 390 and U.S. Pat. No. 4,399,065 disclose the use of certain peptide aldehydes derivatives for the inhibition of blood coagulation. J 90029670 discloses the use of optically active alpha amino aldehydes for the inhibition of enzymes in general. See also "Inhibition of Thrombin and Trypsin by Tripeptide Aldehydes", Int. J. Peptide Protein Res., Vol 12 (1978), pp. 217-221; Gaal, Bacsy & Rappay, and "Tripeptide Aldehyde Protease Inhibitors May Depress in Vitro Prolactin and Growth Hormone Release" Endocrinology, Vol. 116, No. 4 (1985), pp. 1426-1432; Rappay, Makara, Bajusz & Nagy. Certain peptide aldehydes have also been disclosed in EP-A-473 502 for inhibiting protease-mediated skin irritation.
In particular see EP185,390, WO 94/04651, published Mar. 3, 1994, WO 94104652, published Mar. 3, 1994, EP 583,536, published Feb. 23, 1994, EP 583,535, published Feb. 3, 1994, EP 583,534, published Feb. 23, 1994, WO 93/13125, published Jul. 8, 1993, U.S. Pat. No. 4,529,525, U.S. Pat. No. 4,537,706, U.S. Pat. No. 4,537,707, and U.S. Pat. No. 5,527,487.
SUMMARY OF THE INVENTION
The invention herein is a liquid detergent composition comprising: is hydrogen or CF.sub.3 ; Z is an N-capping moiety selected from the group consisting of sulfonamides, phosphoramidates, thioureas, sulfenam
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Huber Alan Carl
McIver John McMillan
McKillop Kirsten Louise
Cook C. Brant
Fries Kery
The Procter & Gamble & Company
Waugh Kevin
Zerby Kim Wm.
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