Chemistry: physical processes – Physical processes – Crystallization
Patent
1975-11-12
1977-03-08
Serwin, R.E.
Chemistry: physical processes
Physical processes
Crystallization
G01N 2146, G01N 23201, G01N 23207
Patent
active
040110460
ABSTRACT:
Using a standardized cell containing a thin layer of an aligned nematic liquid crystalline material, a relationship is determined between concentration of an optically active solute material in the liquid crystal layer and line spacing in a pattern produced by differential light refraction, upon the injection of different amounts of the optically active compound. Subsequently, quantitative analysis of a sample containing the optically active compound is accomplished by injecting a known amount of the sample into a second identical standardized cell, observing the line spacing of refracted light in the second cell and comparing it to the relationship determined in the first cell. Optically active compounds analyzable in this manner include steroids and cholesteryl esters. A preferred nematic liquid crystalline material is n-p-methoxybenzylidene-p-n-butylaniline. A specific system described consists of cholesteryl-2-methyl valerate in homeotropically aligned n-p-methoxybenzylidene-p-n butylaniline with a layer thickness in the cell of 12.7 microns.
REFERENCES:
van Meter, J. P., "Chemistry of Liquid Crystals," Eastman Organic Chemical Bulletin 45, No. 1, (1973).
Buckingham et al., Chem. Phys. Lett. 3, 540, (1969).
Haas, et al., ibid. 14, 95 (1972).
Hakemi et al., J. Chem. Phys. 61, No. 10, 4020, (1974).
Baessler, et al., Ibid. 52, No. 2, 631, (1970).
Gaubert, Comptes Rendues 207, 1052, (1938).
Gaubert, Ibid. 208, 43, (1939).
Penot, et al., Tetrahedron Letters 37, 4031, (1968).
Cano, et al., C. R. Acad. Sc. Paris t.259, 352, (1964).
Adams et al., "The Effective Rotary Power of the Fatty Esters of Cholesterol," Liquid Crystals and Ordered Fluids, (New York: Plenum Press, 1970), 463.
Serwin R.E.
Temple University
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