Liquid controlled release formulations and method of producing s

Details Liquid controlled release formulations and method of producing s Liquid controlled release formulations and method of producing s

1987-03-27

1989-08-15

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424440, 514937, A61K 966

Patent

active

048573353

ABSTRACT:
Liquid, controlled release formulations are provided by emulisifying an aqueous active ingredient-polymer complex, an organic solution of a film-forming polymer and an organic solvent, and a surfactant to form a first emulsion. An aqueous solution of a surfactant is emulsified with the first emulsion to produce a second emulsion and the organic solvent is subsequently removed to produce a liquid controlled release formulation. The formulation so produced includes an aqueous dispersion of microcapsules having permeable shells of the film-forming polymer and aqueous cores of the aqueous active ingredient-polymer complex.

REFERENCES:
patent: 4652441 (1987-03-01), Okada
patent: 4711782 (1987-12-01), Okada

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