Liquid chromatography pumping system with compensation means for

Details Liquid chromatography pumping system with compensation means for Liquid chromatography pumping system with compensation means for

1975-11-10

1977-06-28

Adee, John

Liquid purification or separation

Flow, fluid pressure or material level, responsive

Diverse sensing means

210137, 210198C, B01D 1508

Patent

active

040324451

ABSTRACT:
In a liquid chromatography system including a chromatographic column, a reservoir for a slightly compressible liquid mobile phase, piston means cooperating with the reservoir for pumping the liquid phase through the chromatographic column, and means for displacing the piston at a pre-selected velocity, an improvement is disclosed enabling maintenance of a constant flow in the presence of flow resistance changes at the chromatographic column. Such flow resistance changes may arise, for example, in consequence of viscosity changes occurring in the liquid phase during the course of gradient elution operation. According to the improvement, pressure control means are provided in the flow path between the reservoir and column, the pressure control means being adapted for maintaining a substantially constant pressure at the reservoir. In consequence, flow rate changes arising from expansion or contraction of the liquid phase in consequence of compressibility are precluded.

REFERENCES:
patent: 2036489 (1936-04-01), Murphy
patent: 2143229 (1939-01-01), Russel
patent: 3446057 (1969-05-01), Bakalyar et al.
patent: 3670890 (1972-06-01), Hall et al.
patent: 3779384 (1973-12-01), Stahlkopf
patent: 3917531 (1975-11-01), Magnussen
Introduction to Modern Liquid Chromatography by Spraer et al.
John Wiler & Sons, New York, pp. 94, 97, and 99-102 relied on, 1974.

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