Chemistry: physical processes – Physical processes – Crystallization
Patent
1975-02-27
1976-12-14
Serwin, R.E.
Chemistry: physical processes
Physical processes
Crystallization
23230R, 73 611C, 210198C, G01N 3108
Patent
active
039972984
ABSTRACT:
Liquid chromatography-mass spectrometer apparatus and method are disclosed for analyzing the components of a complex mixture, characterized in that at least a portion of the eluted effluent from the liquid column is continuously introduced directly into the ionization chamber of a chemical ionization mass spectrometer for detection of the eluted sample components. Use is made of restricted capillary tube means for introducing the complex mixture directly into the chemical ionization ion source chamber, and diffusion pump and cryogenic pump means for obtaining the desired vacuum in the ion source chamber. The solvent is used as the agent necessary for chemical ionization, thereby making it unnecessary to remove all of the solvent before introducing the sample into the analyzer. Mass spectra is taken either on a repetitive basis, or the instrument is operable to monitor the total abundance of peaks other than those resulting from the solvent.
REFERENCES:
patent: 3292420 (1968-12-01), Scott
patent: 3718432 (1973-02-01), Roth
Karasek et al., "Separation and Identification of Multicomponent Mixtures Using Centri-Chromatography/Mass Spectrometry," Anal. Chem. vol. 44, No. 8, (July 1972), pp. 1488- 1490.
Baldwin Michael A.
McLafferty Fred W.
Barnard Ralph R.
Cornell Research Foundation Inc.
Laubscher Lawrence E.
Serwin R.E.
Wood Theodore C.
LandOfFree
Liquid chromatography-mass spectrometry system and method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Liquid chromatography-mass spectrometry system and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Liquid chromatography-mass spectrometry system and method will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1342401