Liquid chromatographic chiral stationary phase

Details Liquid chromatographic chiral stationary phase Liquid chromatographic chiral stationary phase

1988-12-09

1990-04-24

Therkorn, Ernest G.

Liquid purification or separation

With means to add treating material

Chromatography

2105021, 210635, 210656, 502401, B01D 1508

Patent

active

049198033

ABSTRACT:
A novel packing material for liquid chromatographic use is disclosed. This packing material is prepared by covalently bonding (S)- or (R)-6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid (naproxen) to aminopropylsilanized silica. The resulting chiral stationary phase is effective for the resolution of enantiomeric (RS)-naproxen, and of other racemic .alpha.-methylarylacetic acids.

REFERENCES:
patent: 4290893 (1981-09-01), Hare et al.
patent: 4318819 (1982-03-01), Malloy et al.
patent: 4318820 (1982-03-01), Malloy et al.
patent: 4322310 (1982-03-01), House
patent: 4512898 (1985-04-01), Oi et al.
patent: 4604207 (1986-08-01), Oi et al.
patent: 4818394 (1989-04-01), Okamoto

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