Liquid chromatograph/mass spectrometer interface

Details Liquid chromatograph/mass spectrometer interface Liquid chromatograph/mass spectrometer interface

1978-05-30

1979-07-03

Dixon, Harold A.

Radiant energy

Ionic separation or analysis

250283, 250423R, B01D 5944

Patent

active

041601610

ABSTRACT:
Method and apparatus for interfacing a liquid chromatograph column and a mass spectrometer. The ions necessary for analysis by a mass spectrometer are provided by utilizing a conduit held at a high voltage potential to ionize at least a portion of the solute flowing out of the liquid chromatograph column. Chambers held at low pressure are utilized to evaporate substantially all of the un-ionized solvent present with the solute to provide an ion stream consisting essentially of ionized solvent and solute to the mass spectrometer. The mass of the ionized solute is then determined by the mass spectrometer, thus providing an analysis of the components eluted from the liquid chromatograph column.

REFERENCES:
patent: 3742213 (1973-06-01), Cohen et al.
patent: 4023398 (1977-05-01), French et al.
patent: 4121099 (1978-10-01), French et al.
"Molecular Beams of Macroions" by Dole et al., Journal of Chemical Physics, vol. 49, No. 5, Sep. 1, 1968.

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