Liquid bismuth containing medicinal product, process for produci

Details Liquid bismuth containing medicinal product, process for produci Liquid bismuth containing medicinal product, process for produci

1989-10-04

1991-11-12

Friedman, Stanley

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

A61K 3129

Patent

active

050648578

ABSTRACT:
The invention relates to a liquid, bismuth containing medicinal product for the oral treatment of gastro-intestinal illnesses such as gastritis, ulcers, etc., caused by campylobacter.
The invention provides a closed system, e.g. a single dose container or a multiple dose container with dosing device containing one or more portions of the bismuth containing medicinal product. In addition, a simple, inexpensive production process is proposed, in which the bismuth citrate is suspended in water, slightly heated and, accompanied by the addition of caustic potash solution/aqueous ammonia solution, is dissolved and set to a pH-value between 6.0 and 7.0 Subsequently an aqueous tripotassium citrate-citric acid solution is added and if necessary sterilized. The solution obtained is placed in a multidose container with dosing device, or is initially diluted with water to form a ready to drink solution, portioned into single dose containers and optionally sterilized.

REFERENCES:
patent: 4801608 (1989-01-01), Bos et al.
patent: 4956386 (1990-02-01), McLoughlin

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