Liquid active ingredient concentrates for preparation of microem

Details Liquid active ingredient concentrates for preparation of microem Liquid active ingredient concentrates for preparation of microem

1983-06-28

1986-01-28

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 78, A61K 3170, A61K 31685

Patent

active

045671613

ABSTRACT:
Liquid, active substance formulations containing an active substance insoluble or poorly soluble in water, or a mixture, a phospholipid, a special co-emulsifier (glycerinester in which the 1 or 2 OH groups have been esterized with hydrocarbon atoms of 8-16, preferably 8-10, C atoms by means of fatty acids and the 3 or remaining OH group of the glycerin body has been etherized with polyethyleneglycol, specifically, with 6-30, preferably 6-15 ethyleneoxide units) and a liquid carrier, the molar ratio of phospholipid to co-emulsifier being from 1:1 to 1:4, and the formulations being such that when added to water they form a transparent liquid system in the form of a microemulsion, with a degree of fineness of 10-200 nm in the lipid phase.

REFERENCES:
patent: 3169094 (1965-02-01), Wretlind
patent: 3203862 (1965-08-01), Jones

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