Lipoxygenase inhibitors

Details Lipoxygenase inhibitors Lipoxygenase inhibitors

1984-02-09

1987-11-24

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514532, 514570, 514863, 514826, 514830, 514859, 514 23, 514464, 514469, 514 64, 514559, 514718, 514731, A61K 3134, A61K 31065

Patent

active

047089644

ABSTRACT:
This invention provides methods of using a number of compounds for the inhibition of lipoxygenase in humans. Pathological conditions which may be treated by the compounds described herein include psoriasis, cellular proliferation, skin allergies, insect bites, allergic rhinitis, conjunctivitis, hay fever, bronchial asthma, allergic gastroenteritis, uterine contractions, hyperactivity of the colon and bronchospasms.

REFERENCES:
patent: 2984674 (1961-05-01), Rutschmann et al.
patent: 3054802 (1962-09-01), Rutschmann et al.
patent: 3408441 (1968-10-01), von Wartburg et al.
patent: 3502770 (1970-03-01), Renz et al.
patent: 3524844 (1970-08-01), Keller-Juslen et al.
patent: 3634459 (1972-01-01), von Wartburg et al.
patent: 3896238 (1975-07-01), Smith
patent: 4294763 (1981-10-01), Kende et al.
patent: 4358461 (1982-11-01), Maki et al.
patent: 4391982 (1983-07-01), Kende et al.
patent: 4442099 (1984-04-01), Nicolaou et al.
patent: 4451475 (1984-05-01), Busse et al.
Funk et al., A New Class of Lipoxygenase Inhibitor, Biochem. Biophys. Research Commun., 114(3), 937 (1983).
Bokech et al., Evidence for Inhibition of Leukotriene Au Synthesis by 5,8,11,14-Eicosatetraynoic Acid . . . , Chem. Abstracts 95:21862j (1981).
Walenga et al., . . . Inhibition of . . . Arachidonic Acid Metabolism . . . by Nordihydroguaiaretic Acid, Chem. Abstracts 93:201893n (1980).
Nicholas et al., Nordihydroguaiaretic Acid . . . as Inhibitors of . . . Lipoxygenase, Chem. Abstracts 87:147795t (1977).
Penneys et al., Inhibitor(s) of Prostoglandin Synthesis Psoriasis, Chem. Abstracts 89:73623c (1977).
F. Fiebrich, et al., "Silymarin, an Inhibitor of Lipoxygenase", Experientia 35(1979), p. 1548.
J. Baumann, et al., "Flavonoids and Related Compounds as Inhibitors of Arachidonic Acid Peroxidation", Prostaglandins, vol. 20, No. 4, pp. 627-637, Oct. 1980.
K. V. Honn, et al., "Nafazatrom (Bay g 6575) Inhibition of Tumor Cell Lipoxygenase Activity and Cellular Proliferation", FEBS Letters, vol. 139, No. 1, pp. 65-68, Mar., 1982.
R. V. Panganamala, et al., "Differential Inhibitory Effects of Vitamin E and other Antioxidants in Prostaglandin Synthetase, Platelet Aggregation and Lipoxidase, Prostaglandins, vol. 14, No. 2, pp. 261-264, Aug., 1977.
K. Yasumoto, et al., "Effect of Phenolic Antioxidants on Lipoxygenase Reaction", Agr. Biol. Chem., vol. 34, No. 8, pp. 1162-1168, 1970.
Y. Koshiara, et al., "Selective Inhibition of 5-Lipoxygenase by Natural Compounds Isolated from Chinese Plants, Artemisia rubripes Nakai", FEBS, vol. 158, No. 1, p. 41, Jul., 1983.
M. O. Funk, Jr., et al., "A New Class of Lipoxygenase Inhibitor. Polyunsaturated Fatty Acids Containing Sulfur", Bioch. and Bioph. Res. Comm., vol. 114, No. 3, pp. 937-943, 1983.
C. D. Perchonock, et al., "Dimethyleicosatrienoic Acids: Inhibitors of the 5-lipoxygenase Enzyme", Tetrahedron Letters, vol. 24, No. 24, pp. 2457-2460, 1983.
J. R. Pfister, et al., "Synthesis of Three Potential Inhibitors of Leukotriene Biosynthesis", J. Medicinal Chemistry, vol. 26, No. 8, pp. 1100-1103, 1983.
J. J. Voorhees, et al., "Leukotrienes and other Lipoxygenase Products in the Pathogenesis and Therapy of Psoriasis and Other Dermatoses", Arch. Dermatol., vol. 119, pp. 541-547, Jul. 1983.
H. W. Chan, "Soya-bean Lipoxygenase: an Iron-Containing Dioxygenase", Biochimica et Biophysica Acta, 327, pp. 32-35, 1973.
J. E. Greenwald, et al., "Role of Ferric Iron in Platelet Lipoxygenase Activity", Bioch. and Bioph. Res. Communications, vol. 96, No. 2, pp. 817-822, Sep. 30, 1980.
M. Hamberg, et al., "On the Specificity of the Oxygenation of Unsaturated Fatty Acids Catalyzed by Soybean Lipoxidase", J. Biol. Chem., vol. 242, No. 22, pp. 5329-5335, Nov., 1967.
N. Nelson, et al., "Prostaglandins and the Arachidonic Acid Cascade", Chem. & Eng. News, vol. 60, p. 30, Aug. 6, 1982.
B. Samuelsson, et al., "Introduction of a Nomenclature: Leukotrienes", Prostaglandins, vol. 17, No. 6, pp. 785-787, Jun. 1979.
B. Samuelsson, "Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation", Science, vol. 220, pp. 568-575, May 6, 1983.
R. H. Green, et al., "Leukotrienes", Tetrahedron, vol. 39, No. 10, pp. 1687-1721, 1983.
PCT Patent Application, K. C. Nicolau, "Luekotriene Analogues", filed in the U.S. Nov. 27, 1981, published in the PCT Gazette as No. WO 83/01897 on Jun. 9, 1983.
Satoshi Yamamoto, et al., "Turmor Promoter 12-O-Tetradecanoylphorbol-13-Acetate-Induced Insulin Secretion: Inhibition by Phospholipase A.sub.2 -And Lipoxygenase-Inhibitors", Biochemical and Biophysical Research Communications, vol. 105, No. 2, pp. 759-765, Mar. 30, 1982.
Teruo Nakadate, et al., "Inhibition of 12-O-Tetradecanoylphorbol-13-Acetate-Induced Epidermal Ornithine Decarboxylase Activity by Lipoxygenase Inhibitors: Possible Role of Product(s) of Lipoxygenase Pathway", Carcinogenesis, vol. 3, No. 12, pp. 1411-1414, 1982.
M. Volpi, et al., "Arachidonate Metabolite(s) Increase the Permeability of the Plasma Membrane of the Neutrophils to Calcium", Biochem. and Biophys. Res. Commun., 92:1231-1237, 1980.
H. L. Bumpers, et al., "The Effect of a Novel C-5 Inhibitor (K-76 COONa) on Tumor Cell Chemotaxis", J. Lab. and Clinic. Med., 102:421-427, 1983.
K. V. Honn, et al., "Prostacyclin, Thromboxanes, and Hemotogenous Metastasis", Advance. Prostagland. Thrombox. and Leukotriene Res., 12:313-318, 1983.

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