Lipoxygenase inhibitors

Details Lipoxygenase inhibitors Lipoxygenase inhibitors

1983-04-25

1985-07-02

Lone, Werren B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

260404, 260408, 260410, 2604105, 560101, 560102, 560123, 560125, 560126, 560128, 564123, 564163, 564164, 564166, 568591, 568592, 568669, 568670, 568704, 568715, 568774, 568821, 514715, 514729, 514826, 514929, C07C 3520, C07C 4318

Patent

active

045269998

ABSTRACT:
Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit lipoxygenase, thus preventing the metabolism of arachidonic acid to the leukotrienes. These compounds are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.

REFERENCES:
patent: 3993674 (1976-11-01), Schaub et al.
D. Bailey et al, Ann Rpts. Med. Chem., 17, 203-217, (1982).
R. C. Murphy et al., PNAS, USA, 76, 4275, (1979).
J. L. Humes et al., J. Biol. Chem., 257, 1591, (1982).
H. R. Morris et al., Prostagand.
M. E. Vol'pin et al., Zh. Obsh. Khim., 29, s855, (1959).

Affiliated with

Also associated with

Rating

Lipoxygenase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lipoxygenase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipoxygenase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-382537