Lipoxygenase inhibiting compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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2605005H, 2605011, 26050115, 514555, C07C 8310, A61K 31185, A61K 31205

Patent

active

046236619

ABSTRACT:
Compounds of the formula ##STR1## where R.sub.1 is a trinuclear aromatic or biaryl group; R.sub.2 is hydrogen or C.sub.1 to C.sub.6 alkyl or cycloalkyl; n is 0 or 1; and M is a pharmaceutically acceptable cation, are potent inhibitors of the enzymes 5-, 12-, and 15-lipoxygenase.

REFERENCES:
patent: 3268542 (1966-08-01), Burk et al.
patent: 3507900 (1970-04-01), Burk et al.
patent: 3560518 (1971-02-01), Burk et al.
patent: 3565944 (1971-02-01), Lee et al.
patent: 3681445 (1972-08-01), Ruyle et al.
patent: 3859299 (1975-01-01), Hocker et al.
patent: 4109013 (1978-08-01), Grill et al.

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