Lipoxygenase and cyclogenase inhibiting thiachromen and thiepan

Details Lipoxygenase and cyclogenase inhibiting thiachromen and thiepan Lipoxygenase and cyclogenase inhibiting thiachromen and thiepan

1986-09-16

1987-10-13

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514432, 549 9, 549 23, A61K 3138, C07D33506, C07D33708

Patent

active

046999191

ABSTRACT:
This invention relates to bicyclic catechol derivatives having the general formulae I and II ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and Z represent various substituents, to a preparation process of the same comprising reacting a compound of formula III ##STR2## wherein R.sub.1 and R.sub.2 have the meanings given above with an appropriately substituted propionic or butyric acid (or an ester or a salt of the same) of formula IV ##STR3## wherein R.sub.3 has the meaning given above, and to therapeutical compositions wherein the active ingredient is one of these compounds.

REFERENCES:
patent: 4436749 (1984-03-01), Hatinguais et al.
Shen et al, "The Development of Antiasthma Drugs", Part III, ed, D. R. Buckle et al., Butterworth Publishers, Kent, England, 1984.

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