Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-03-11
1998-05-12
Allen, Marianne P.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 4051, 436 71, G01N 3353
Patent
active
057503540
ABSTRACT:
A lipoxin transport system which mediates uptake of lipoxin by cells is disclosed. Lipoxin transport into cells by the lipoxin transport system is inhibitable by 3,5-diiodosalicylic acid (DISA), pentachlorophenol (PCP), .alpha.-cyano-.beta.-(1-phenylindol-3-yl)acrylic acid (UK-5099), mersalyl and p-hydroxymercuribenzoate (pHMB). The invention provides methods for identifying inducers, enhancers and inhibitors of the lipoxin transport system. The invention further provides methods for inducing, enhancing or inhibiting lipoxin transport by the lipoxin transport system. Methods for identifying molecules which are transported by the lipoxin transport system, including lipoxin analogs, are also disclosed. Modulation of physiological responses by modulation of lipoxin transport into cells by the lipoxin transport system of the invention are also contemplated.
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Sted Man's Medicare Dictionary .degree.1982 by Waverly Press Inc. p. 1084.
Serhan Charles N.
Simchowitz Louis
Allen Marianne P.
Brigham and Women's Hospital
Duffy Patricia A.
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