Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1995-05-31
1997-07-15
Geist, Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
560 19, 560103, 560187, 562587, C07C32108, C07C 6966, C07C 59105
Patent
active
056485123
ABSTRACT:
Compounds having the active site of natural lipoxins, but a longer tissue hlf-life are disclosed. These small molecules are useful for treating vasoconstrictive, inflammatory, myeloid suppressive, cardiovascular, and gastrointestinal diseases.
REFERENCES:
patent: 4560514 (1985-12-01), Samuelsson et al.
patent: 4576758 (1986-03-01), Morris
patent: 5049681 (1991-09-01), Sato
patent: 5079261 (1992-01-01), Serhan et al.
Corey et al., "On the Synthesis.. Lipoxin B", Tetrahedron Letters, vol. 26, No. 16, pp. 1919-1922. 1985.
Brady, et al., "Leukotrienes Stimulate Neutrophil Adhesion to Mesangial Cells: Modulation with Lipoxins", American Journal Physiology, (1990), vol. 259, pp. F809-F815.
Fiore, et al. "Lipoxin Recognition Sites", The Journal of Biological Chemistry (1992), vol. 267, No. 23, pp. 16168-16176.
Katoh, et al., "Renal Hemodynamic Actions of Lipoxin in Rats: A Comparative Physiological Study", American Journal Physiology, (1992), vol. 263, pp. F436-F442.
Lee, et al., "Inhibition of Leukotriene B.sub.4 -Induced Neutrophil Migration by Lipoxin A.sub.4 : Structure-Function Relationships", Biochemical and Biophysical Research Communications, (1991), vol. 180, No. 3, pp. 1416-1421.
Mizukami, et al., ".omega.-Hydroxylation of Lipoxin B.sub.4 by Human Neutrophil Microsomes: Identification of .omega.-hydroxy Metabolite of Lipoxin B.sub.4 and Catalysis by Leukotriene B.sub.4 .omega.-hydroxylase (cytochrome P-450LTB.omega.)", Biochimica et Biophysica Acta (1993), No. 1168, pp. 87-93.
Nicolaou, et al., "Lipoxins and Related Eicosanoids: Biosynthesis Biological Properties, and Chemical Synthesis", Angew, Chem. Int. Ed. Engl., (1991), vol. 30, pp. 1100-1116.
Nicolaou, et al., "Identification of a Novel 7-cis-11-trans-lipoxin A.sub.4 Generated by Human Neutrophils: Total Synthesis, Spasmogenic Activities and Comparison with Other Geometric Isomers of Lipoxin A.sub.4 and B.sub.4 ", Biochimica et Biophysica Acta, (1989), No. 1003, pp. 44-53.
Nicolaou, et al., "Total Synthesis of Novel Geometric Isomers of Lipoxin A.sub.4 and Lipoxin B.sub.4 ", Reprint from The Journal of Organic Chemistry (1989), vol. 54, No. 23, pp. 5527-5535.
Nigam, et al., "Lipoxin A.sub.4 and Lioxin B.sub.4 Stimulate the Release but Not the Oxygenation of Arachidonic Acid in Human Neutrophils: Dissociation between Lipid Remodeling and Adhesion", Journal of Cellular Physiology, (1990), vol. 143, pp. 512-523.
Popov, et al., "Effect of Lipoxin B on Cology-Forming Ability of Human Peripheral Blood Mononuclears in a Diffusion Chamber", Translated from Byulleten' Eksperimental' noi Biologii i Medisiny, (1989), vol. 107, No. 1, pp. 80-83.
Serhan, "Lipoxins: Eicosanoids Carrying Intra-and Intercellular Messages", Journal of Bioenergetics and Biomembranes, (1991), vol. 23, No. 1, pp. 105-122.
International Search Report (Form PCT/ISA/220) in PCT/US94/95722 which was mailed Oct. 10, 1994.
Brigham & Women's Hospital
Geist Gary
Williams Rosalynd
LandOfFree
Lipoxin compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lipoxin compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipoxin compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1493449