Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1992-01-23
1994-08-23
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
4241931, 424812, A61K 3722, A61K 3902
Patent
active
053405889
ABSTRACT:
Solid, water-insoluble lipospheres including a solid hydrophobic core, having a layer of a phospholipid embedded on the surface of the core, that contain an antigen are disclosed for use in immunizing an animal. The antigen (or "immunogen"), alone or in combination with a carrier, can form the core, be attached to or within the phospholipid, or both. Lipospheres containing antigens are prepared by two general procedures, either melt preparation or solvent preparation. The resulting lipospheres have several advantages over other delivery systems, including emulsions, vesicles and liposomes, including stability, low cost of reagents, ease of manufacture, high dispersibility in an aqueous medium, a release rate for the entrapped substance that is controlled by the phospholipid coating and the carrier.
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Levy Neil
Nova Pharmaceutical Corporation
Page Thurman K.
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