Liposomes with enhanced entrapment capacity and their use in ima

Details Liposomes with enhanced entrapment capacity and their use in ima Liposomes with enhanced entrapment capacity and their use in ima

1997-08-12

1999-11-09

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 264 43, 264 46, 4284022, A61K 9127

Patent

active

059809370

ABSTRACT:
The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm.sup.3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacity by dissolving one or more film forming lipids in at least one organic solvent to form a solution in a reaction vessel, evaporating the solvent to form an expanded three dimensional porous lipid structure, contacting the lipid deposit with an aqueous carrier phase, and producing liposome vesicles entrapping the carrier phase as well as an apparatus comprising an array of tubing or an inert packing which serves as a material support or a matrix surface for the deposition of lipids produced according to the method.

REFERENCES:
patent: 4162282 (1979-07-01), Fulwyler
patent: 4485054 (1984-11-01), Mezei
patent: 4508703 (1985-04-01), Redziniak et al.
patent: 4619795 (1986-10-01), Cohen
patent: 4622188 (1986-11-01), Adamich
J. Fibe U. M. Regitz `Rompp-Chemie-Lexikon, 9th Edition vol. 3` 1990, Georg Verlag Stuttgart (DE) pp. 1860-1861 "HPLC".

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