Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1989-10-20
1991-05-07
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424 11, 264 43, A61K 3722
Patent
active
050135562
ABSTRACT:
A liposome composition which contains between 1-20 mole percent of an amphipathic lipid derivatized with a polyalkylether, as exemplified by phosphatidylethanolamine derivatized with polyethyleneglycol. The derivatized lipid enchances the circulation time of the liposomes severalfold, and this enhancement is achieved with either fluid or membrane-rigidifying liposome components. Also disclosed are methods for delivering a drug for slow release from the bloodstream, and for targeting a selected tissue or cells with liposomes, via the bloodstream.
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Martin Francis J.
Redemann Carl T.
Woodle Martin C.
Yau-Young Annie
Dehlinger Peter J.
Liposome Technology, Inc.
Page Thurman K.
Prater P. L.
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