Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1986-12-24
1989-06-06
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
264 43, 424 11, 4284022, 435 5, 436829, A61K 966, A61K 3722, B01J 1302
Patent
active
048370282
ABSTRACT:
A composition of liposomes which contain an entrapped pharmaceutical agent and are characterized by: (a) liposome sizes predominantly between about 0.08 and 0.5 microns: (b) at least about 50 mole percent of a membrane-rigidifying component, such as sphingomyelin or neutral phospholipids with predominantly saturated acyl chains: and (c) between about 5-15 mole percent ganglioside G.sub.M1. The liposomes show a blood/RES tissue distribution ratio, two hours after intravenous administration, which is substantially greater than the sum of the distribution ratios observed with similarly constructed liposome compositions containing the membrane-rigidifying agent alone and gangliosides alone. Also disclosed are methods for enhancing the blood/RES ratio of intravenously administered liposomes, and for assessing the effect of selected liposome components on in vivo uptake of liposomes by cells of the reticuloendothelial system (RES).
REFERENCES:
patent: 4416872 (1983-11-01), Alving et al.
patent: 4515736 (1985-05-01), Deamer
patent: 4598051 (1986-07-01), Papahadjopoulos et al.
patent: 4684625 (1987-08-01), Eppstein et al.
Liposome Technology, Inc.
Lovering Richard D.
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