Liposomes with enhanced circulation time

Details Liposomes with enhanced circulation time Liposomes with enhanced circulation time

1987-12-18

1990-04-24

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 43, 264 46, 424 11, 424 943, 4284022, 436829, 514885, A61K 3722, A61K 966, B01J 1302

Patent

active

049200160

ABSTRACT:
A composition of liposomes which contain an entrapped pharmaceutical agent and are characterized by (a) liposome sizes predominantly between about 0.07 and 0.5 microns; (b) at least about 50 mole percent of a membrane-rigidifying lipid, such as sphingomyelin or neutral phospholipids with predominantly saturated acyl chains; and (c) between about 5-20 mole percent of a glycolipid selected from the group consisting of ganglioside GM.sub.1, saturated phosphatidylinositol, and monogalactosyl stearate. The liposomes show high blood/RES tissue distribution ratios, and are effective for drug administration to tumors via intravenous drug delivery.

REFERENCES:
patent: 2870179 (1959-01-01), Jacini
patent: 4416872 (1983-11-01), Alying et al.
patent: 4460577 (1984-07-01), Moro et al.
patent: 4515736 (1985-05-01), Deamer
patent: 4565696 (1986-01-01), Heath et al.
patent: 4598051 (1986-07-01), Papahadjopoulos et al.
patent: 4684625 (1987-08-01), Eppstein et al.

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