Liposomes for treatment of B-cell and T-cell disorders

Details Liposomes for treatment of B-cell and T-cell disorders Liposomes for treatment of B-cell and T-cell disorders

1995-06-07

1997-04-15

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

4241811, 424450, 424812, 4241801, 5303917, A61K 5112, A61K 3944, A61K 9127, C07K 1700

Patent

active

056206895

ABSTRACT:
A method of treating a subject having a disorder characterized by a neoplasm of B-lymphocyte or T-lymphocyte lineage cells is described. The method includes administering a suspension of liposomes having a surface coating of polyethylene glycol chains. Attached to the distal ends of the chains are antibodies or antibody fragments effective to bind to an antigen specific to the affected cells. In one embodiment, anti-CD19 antibodies are attached to the liposome-bound chains, for treatment of multiple myeloma.

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