Liposomes encapsulating doxorubicin

Details Liposomes encapsulating doxorubicin Liposomes encapsulating doxorubicin

1994-11-23

1997-02-25

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

A61K 9127

Patent

active

056057032

ABSTRACT:
Liposomes encapsulating doxorubicin, which contain, incorporated into them, a protector compound of general formula A or B, in order to reduce the toxicity of the drug when it is administered in intravenous form, and in which formulas R.sub.1 and R.sub.2, are the same or different, independently represented by HO--, CH.sub.3 O-- or CF.sub.3 CH.sub.2 O-- ##STR1##

REFERENCES:
patent: 5318987 (1994-06-01), Weithman
"Inhibition of Rat Liver Microsomal Lipid Peroxidation Elicited by 2,2-Dimethylchromenes and Chromans Containing Fluorinated Moieties Resistant to Cytochrome P-450 Metabolism", Biorganic & Medicinal Chemistry, vol. 1, No. 3, pp. 219-225, Oct. 2, 1993.
"Inhibition of Rat Liver Microsomal Lipid Peroxidation Elicited by Simple 2,2-Dimethylchromenes and Chromans Structurally Related to Precocenes", J. Agric. Food Chem., 1992, 40, 585-590.
International Search Report, Nov. 1996.

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