Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1995-10-03
1998-06-30
Kunz, Gary L.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
514934, A61K 9127, C07H 3170
Patent
active
057730270
ABSTRACT:
A method is disclosed for the treatment of viral diseases comprising the administration of antiviral agents encapsulated in liposomes. Also provided are formulations of liposomes for the treatment of viral diseases and more particularly for the treatment of infections caused by viruses like human immunodeficiency virus (HIV) and cytomegalovirus (CMV). These formulations of liposomes are composed of specific classes of lipid components and contain an entrapped drug effective against the viral disease. These liposomal formulations of antiviral drugs allow high cellular penetration in different cell lines, good in vitro antiviral efficacy against HIV and CMV replication, efficient in vivo targeting of HIV reservoirs and a marked improvement of the pharmacokinetics of drugs.
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Bergeron Michel G.
Desormeaux Andre
Bergeron Michael G.
Kunz Gary L.
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