Liposomes containing the salt of phosphoramide mustard and relat

Details Liposomes containing the salt of phosphoramide mustard and relat Liposomes containing the salt of phosphoramide mustard and relat

1993-11-15

1995-11-21

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

514883, 558199, A61K 3722, A61K 952

Patent

active

054684994

ABSTRACT:
The present invention provides an anti cancer treatment which has an improved stability and does not produce acrolein. The invention includes dichlorodiethyl phosphoramide drugs including, for example, the cyclohexylamine salt phosphoramide mustard and isophosphoramide mustard and mixtures thereof, which have been entrapped by liposomes. Preferably the liposomes contain sphingomyelin and cholesterol.

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patent: 5306727 (1994-04-01), Borch et al.

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