Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1994-03-30
1995-11-14
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
4284022, A61K 9127
Patent
active
054664675
ABSTRACT:
The lipids of this invention are derivatives of phosphatidyl choline having the general chemical formula: ##STR1## wherein at least one of R and R' is a polymerizable unsaturated alkyl group, acid or ester, wherein X includes an iminodiacetic acid in the polymerizable metal chelating lipid (2) and wherein z is an integer from 1-20 including 1 and 20. Lipid microstructures are formed by mixing the polymerizable metal chelating lipid monomers (2) with polymerizable non-chelating lipid monomers wherein X includes a non-chelating group, for example, --N.sup.+ (CH.sub.3).sub.3.
REFERENCES:
patent: 4145410 (1979-03-01), Sears
patent: 4867917 (1989-09-01), Schnur et al.
patent: 4913902 (1990-04-01), Kilpatrick et al.
patent: 5009956 (1991-04-01), Bauman
patent: 5258499 (1993-11-01), Konigsberg et al.
patent: 5290960 (1994-03-01), Singh
Singh et al Am. Chem. Soc. Meeting Abst. #79, Mar.-Apr. 1993.
Singh, A., and Schnur, J. M., Chapter 7-Polymerizable Phospholipids in Phholipids Handbook, Gregor Cevc (Editor), Marcell Dekker, Inc., New York, pp. 233-291 (1993).
Ringsdorf, H., Schlarb B., Venzmer, J., 27 Angew. Chem. Int. Ed. Engl. p. 113 (1988).
Regen, S. L., Kirzenstejn, P., Singh, A., Macromolecules p. 335 (1983).
Markowitz, M., Schnur, J., and Singh, A., The influence of the polar headgroups of acidic diacetylenic phospholipids on tubule formation, microstructure morphology and Langmuir film behavior, 62 Chemistry and Physics of Lipids, pp. 193-204 (1992).
Markowitz, M., Baral, S., Brandow, S., and Singh, A., Palladium ion assisted formation and metallization of lipid tubules, 224 Thin Solid Films pp. 242-247 (1993).
Wasserman et al., High-Yield Method for Immobilization of Enzymes, 22 Biotechnology and Bioengineering pp. 271-287 (1980).
Epton et al., A Study of Carbonic Anhydrase Covalently Bound to a Poly(acryloylmorpoline) Network in Aqueous/Organic Solvents, 5(1) Biochemical Society Transactions pp. 274-276 (1977).
Crumbliss et al., Preparation and Activity of Carbonic Anhydrase Immbolizied on Porous Silica Beads and Graphite Rods, 31 Biotechnology and Bioengineering pp. 796-801 (1988).
Cantenys et al., Covalent Attachment of Insulin to the Outer Surface of Liposomes, 117 (2) Biochemical and Biophysical Research Communications, pp. 399-405 (Dec. 16, 1983).
Martin et al., Irreversible Coupling of Immunoglobulin Fragments to Preformed Vesicles, 257(1) The Journal of Biological Chemistry pp. 286-288 (Jan. 10, 1982).
O'Daly et al., Activity of Carbonic Anhydrase Immobilized on Porous Silica Beads in Organic Media, 12 Biotechnology and Applied Biochemistry, pp. 11-19 (1990).
Wulf G., Polymeric Reagents and Catalysis, Ford, W. (Editor), ACS Symposium Series 308, American Chemical Society, pp. 186-230, Washington, D.C. (1986).
Sinha, P. et al., 28A Ind. J. Chem. pp. 33515 (1989).
R. L. Juliano, S. L. Regen, M. Singh, M. J. Hsu and A. Singh, Stability properties of photopolymerized liposomes, 1 Biotechnology pp. 882-885 (1983).
Singh, A., An efficient synthesis of phosphatidylcholines, 31 Journal of Lipid Research, pp. 1522-1525 (1990).
S. L. Regen, A. Singh, G. Oehme, and M. Singh, Polymerized phosphatidylcholine vesicles: Synthesis and characterization J. Amer. Chem. Soc. 104:791-795 (1982).
Kishore Gollamudi S.
McDonnell Thomas E.
Pathak Ajay S.
The United States of America as represented by the Secretary of
LandOfFree
Liposomes containing polymerized lipids for non-covalent immobil does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Liposomes containing polymerized lipids for non-covalent immobil, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Liposomes containing polymerized lipids for non-covalent immobil will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1219350