Liposomes containing oligonucleotides

Details Liposomes containing oligonucleotides Liposomes containing oligonucleotides

1997-10-24

2000-10-03

Guzo, David

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

436 71, 436829, 536 231, 536 245, A61K 9127, C07H 2104

Patent

active

061269654

ABSTRACT:
It is possible to radiosensitize tumor cells by administration of compositions containing the Human antisense c-raf-1 oligodeoxyribonucleotide (ODN/oligo) sequence: 5'-GTGCTCCATTGATGC-3' (seq. #1) wherein only the end bases are phosphorylated is a preferred embodiment. Antisense sequences of up to 40 bases which containing this sequence may be used in accord with the teachings of this disclosure. Compositions comprising a cationic liposome of dimethyldioctadecyl ammonium bromide, phosphatidylcholine and cholesterol may be used as a carrier system. The liposomes provide a new carrier system that is particularly useful for administration of sequences for therapy.

REFERENCES:
patent: 5756122 (1998-05-01), Thierry et al.
patent: 5827703 (1998-10-01), Deb et al.
Maher et al., Specific hybridization arrest of dihydrofolate reductase mRNA in vitro using antisense RNA or antisense oligonucleotides, Archives of Biochemistry and Biophysics, vol. 253 (1), pp. 214-220, Feb. 15, 1987.

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