Liposomes containing modified cholesterol for organ targeting

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...

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424 9, 424 71, 424 16, 424 85, 424 88, 424 94, 2523153, A61K 4900, A61K 4300, A61K 3900

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045445451

ABSTRACT:
Phospholipid liposomes are provided having an outer layer including a cholesterol derivative such as a cholesterol ester and an aqueous medium confined by the layer which includes a tracer agent, a cytoxic agent or a therapeutic agent. The liposomes are adapted for specific organ targeting.

REFERENCES:
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patent: 4310505 (1982-01-01), Baldeschwieler et al.
patent: 4343895 (1982-08-01), Sugaar
Ryan et al, Biochim. Biophys. Acta, 756, (1983), 106-110.
Stoffel et al, Hoppe-Seyler's Z. Physiol. Chem. 357, (1976), 21-33.

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